DegronMD

Uniprot ID: Q5T2T1

Source protein: MAGUK p55 subfamily member 7

Source gene: MPP7

Class: DEG_COP1_1

Location: 343:354

E3 ligase: COP1

DEGRON score: 0.9986

ASA_SCORE: 78.3083

COIL: 0.7684

CONS_SCORE: 0.3932

DSS_SCORE: 0.41

HELIX: 0.1347

FCONS_SCORE: 1.0448

RIG_SCORE: 0.758

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R362Q	TCGA-A8-A07U	BRCA	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.1111
p.R362Q	TCGA-FW-A3R5	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.1111
p.R362Q	SIDM01483	Melanoma	GDSC	SDQYDTADVPTY	DEG_COP1_1	0.1111
p.R362Q	ACH-000582	Skin Cancer	CCLE	SDQYDTADVPTY	DEG_COP1_1	0.1111
p.R362Q	COLO-741	large_intestine	COSMIC	SDQYDTADVPTY	DEG_COP1_1	0.1111
p.R361Q	TCGA-AP-A0LM	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.1389
p.R361Q	TCGA-AX-A05S	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.1389
p.K335T	TCGA-AP-A1E0	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.2222
p.T333A	TCGA-B5-A3FA	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.0556
p.Y360C	TCGA-BA-A6DG	HNSC	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.1667
p.D347N	TCGA-BF-AAP2	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.6932
p.D347N	TCGA-DA-A1I1	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.6932
p.A349T	TCGA-BR-7851	STAD	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.6028
p.S336F	TCGA-D3-A2JH	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.1389
p.E355K	TCGA-D9-A6EC	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.3056
p.E355K	TCGA-DA-A1IC	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.3056
p.E355K	TCGA-EB-A44O	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.3056
p.E355K	TCGA-F1-6177	STAD	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.3056
p.P359S	TCGA-EE-A2GC	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	0.1944
p.N363H	DO8264	COAD	ICGC	SDQYDTADVPTY	DEG_COP1_1	0.0833
p.P351S	DO37861	SKCM	ICGC	SDQYDTADVPTY	DEG_COP1_1	0.6752
p.V355I	DO229234	THCA	ICGC	SDQYDTADVPTY	DEG_COP1_1	0.3056
p.A354G	DO41199	UCEC	ICGC	SDQYDTADVPTY	DEG_COP1_1	0.754
p.Y338C	SIDM01045	Endometrial Carcinoma	GDSC	SDQYDTADVPTY	DEG_COP1_1	0.1944
p.Y338C	ACH-000978	Endometrial/Uterine Cancer	CCLE	SDQYDTADVPTY	DEG_COP1_1	0.1944
p.Y338C	EN	endometrium	COSMIC	SDQYDTADVPTY	DEG_COP1_1	0.1944
p.D350G	SIDM01608	Endometrial Carcinoma	GDSC	SDQYDTADVPTY	DEG_COP1_1	0.6087
p.D350G	ACH-000990	Endometrial/Uterine Cancer	CCLE	SDQYDTADVPTY	DEG_COP1_1	0.6087

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SDQYDTADVPTY

Degron related mutations and impact score

Drug responses associated with MPP7 mutations

All proteins holding degron of SDQYDTADVPTY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T2T1	MAGUK p55 subfamily member 7	DEG_COP1_1	343:354	SDQYDTADVPTY	COP1	0.9986	More...