DegronMD

Uniprot ID: Q8NDZ2

Source protein: SUMO-interacting motif-containing protein 1

Source gene: SIMC1

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7896

ASA_SCORE: 83.3889

COIL: 0.6663

CONS_SCORE: 0.2259

DSS_SCORE: 0.4491

HELIX: 0.0301

FCONS_SCORE: 1.031

RIG_SCORE: 0.8013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L49S	TCGA-58-8391	LUSC	TCGA	DRSGLYVID	DEG_APCC_DBOX_1	0.2778
p.E52D	DO44061	BLCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.1944
p.E52D	ACH-001065	Breast Cancer	CCLE	DRSGLYVID	DEG_APCC_DBOX_1	0.1944
p.E52D	EVSA-T	breast	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	0.1944
p.R40S	DO224600	BRCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.7427
p.R40S	DO1011	BRCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.7427
p.T33I	DO227806	BRCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.1667
p.T33I	DO233160	GACA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.1667
p.T33I	DO225401	LAML	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.1667
p.T33I	DO229224	THCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.1667
p.R40C	DO222798	COCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.8301
p.R40C	DO223286	UCEC	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.8301
p.R40C	ACH-000993	Endometrial/Uterine Cancer	CCLE	DRSGLYVID	DEG_APCC_DBOX_1	0.8301
p.R40C	ACH-000996	Endometrial/Uterine Cancer	CCLE	DRSGLYVID	DEG_APCC_DBOX_1	0.8301
p.R50G	DO25123	LUAD	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.25
p.R40H	DO224638	LUSC	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.8244
p.R40H	DO48172	UCEC	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.8244
p.R36K	DO38081	SKCM	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.25
p.E39D	DO38099	SKCM	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	0.6758
p.K57E	SIDM01148	Plasma Cell Myeloma	GDSC	DRSGLYVID	DEG_APCC_DBOX_1	0.0556
p.K57E	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	0.0556
p.V35I	REH	haematopoietic_and_lymphoid_tissue	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	0.2222
p.K38E	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDZ2	SUMO-interacting motif-containing protein 1	DEG_APCC_DBOX_1	39:47	DRSGLYVID	APC,CDC20,FZR1	0.7896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons