DegronMD - Q8NDZ2(SIMC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L49S	TCGA-58-8391	LUSC	TCGA	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.2778
p.G419V	TCGA-85-6561	LUSC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.G419V	DO26518	LUSC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.V430A	TCGA-AA-3967	COAD	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6936
p.V430A	DO10124	COAD	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6936
p.A441V	TCGA-AP-A0LM	UCEC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.A441V	TCGA-P3-A5Q5	HNSC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.A441V	DO44450	HNSC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.A441V	DO43306	UCEC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.A441T	TCGA-AX-A2HD	UCEC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.A441T	DO42608	UCEC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1667
p.F438L	TCGA-EB-A299	SKCM	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.25
p.F438L	DO37794	SKCM	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.25
p.E420K	TCGA-EK-A2PG	CESC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1389
p.E420K	DO49939	CESC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1389
p.E52D	DO44061	BLCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1944
p.E52D	ACH-001065	Breast Cancer	CCLE	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1944
p.E52D	EVSA-T	breast	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1944
p.R40S	DO224600	BRCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7427
p.R40S	DO1011	BRCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7427
p.T33I	DO227806	BRCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.T33I	DO233160	GACA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.T33I	DO225401	LAML	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.T33I	DO229224	THCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.L436M	DO1183	BRCA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.3056
p.R439H	DO222769	COCA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2222
p.R40C	DO222798	COCA	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8301
p.R40C	DO223286	UCEC	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8301
p.R40C	ACH-000993	Endometrial/Uterine Cancer	CCLE	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8301
p.R40C	ACH-000996	Endometrial/Uterine Cancer	CCLE	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8301
p.V423F	DO228985	LICA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2222
p.E420D	DO229031	LICA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1389
p.Y436C	DO44978	LIHC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.3056
p.P445S	DO50818	LIRI	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556
p.R50G	DO25123	LUAD	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R40H	DO224638	LUSC	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8244
p.R40H	DO48172	UCEC	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8244
p.P429Q	DO47442	SKCM	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.5924
p.H443Y	DO47368	SKCM	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.R36K	DO38081	SKCM	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.E39D	DO38099	SKCM	ICGC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6758
p.T420A	DO42023	UCEC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1389
p.K57E	SIDM01148	Plasma Cell Myeloma	GDSC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.K57E	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.P424L	ACH-000046	Kidney Cancer	CCLE	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.25
p.P424L	ACHN	kidney	COSMIC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.25
p.K434Q	ACH-000675	Lung Cancer	CCLE	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6944
p.K434Q	NCI-H1734	lung	COSMIC	NRPCLHRLK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6944
p.V35I	REH	haematopoietic and lymphoid tissue	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.2222
p.K38E	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	DRSGLYVID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIMC1

UniProt ID: Q8NDZ2

Entrez ID: 375484

Protein name: SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIMC1 in