DegronMD

Uniprot ID: Q8NDZ2

Source protein: SUMO-interacting motif-containing protein 1

Source gene: SIMC1

Class: DEG_APCC_DBOX_1

Location: 427:435

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5095

ASA_SCORE: 82.1222

COIL: 0.5881

CONS_SCORE: 0.5675

DSS_SCORE: 0.2683

HELIX: 0.3279

FCONS_SCORE: 1.3271

RIG_SCORE: 0.8184

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G419V	TCGA-85-6561	LUSC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	0.1111
p.G419V	DO26518	LUSC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1111
p.V430A	TCGA-AA-3967	COAD	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	0.6936
p.V430A	DO10124	COAD	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.6936
p.A441V	TCGA-AP-A0LM	UCEC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	0.1667
p.A441V	TCGA-P3-A5Q5	HNSC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	0.1667
p.A441V	DO44450	HNSC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1667
p.A441V	DO43306	UCEC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1667
p.A441T	TCGA-AX-A2HD	UCEC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	0.1667
p.A441T	DO42608	UCEC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1667
p.F438L	TCGA-EB-A299	SKCM	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	0.25
p.F438L	DO37794	SKCM	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.25
p.E420K	TCGA-EK-A2PG	CESC	TCGA	NRPCLHRLK	DEG_APCC_DBOX_1	0.1389
p.E420K	DO49939	CESC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1389
p.L436M	DO1183	BRCA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.3056
p.R439H	DO222769	COCA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.2222
p.V423F	DO228985	LICA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.2222
p.E420D	DO229031	LICA	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1389
p.Y436C	DO44978	LIHC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.3056
p.P445S	DO50818	LIRI	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.0556
p.P429Q	DO47442	SKCM	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.5924
p.H443Y	DO47368	SKCM	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1111
p.T420A	DO42023	UCEC	ICGC	NRPCLHRLK	DEG_APCC_DBOX_1	0.1389
p.P424L	ACH-000046	Kidney Cancer	CCLE	NRPCLHRLK	DEG_APCC_DBOX_1	0.25
p.P424L	ACHN	kidney	COSMIC	NRPCLHRLK	DEG_APCC_DBOX_1	0.25
p.K434Q	ACH-000675	Lung Cancer	CCLE	NRPCLHRLK	DEG_APCC_DBOX_1	0.6944
p.K434Q	NCI-H1734	lung	COSMIC	NRPCLHRLK	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDZ2	SUMO-interacting motif-containing protein 1	DEG_APCC_DBOX_1	427:435	NRPCLHRLK	APC,CDC20,FZR1	0.5095	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRPCLHRLK

Degron related mutations and impact score

Drug responses associated with SIMC1 mutations

All proteins holding degron of NRPCLHRLK