DegronMD

Uniprot ID: Q9Y5X3

Source protein: Sorting nexin-5

Source gene: SNX5

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8133

ASA_SCORE: 98

COIL: 0.6436

CONS_SCORE: 0.2957

DSS_SCORE: 0.4508

HELIX: 0.3106

FCONS_SCORE: 0.8718

RIG_SCORE: 0.7234

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q11E	TCGA-CM-4743	COAD	TCGA	DRSKLRSVS	DEG_APCC_DBOX_1	0.25
p.Q11E	DO8103	COAD	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	0.25
p.P5S	DO2593	BRCA	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	0.0833
p.L18M	DO228974	LICA	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	0.711
p.E12Q	DO27120	LUSC	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	0.2778
p.A21V	DO52682	MALY	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	0.6936
p.E6D	DO52675	MALY	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	0.1111
p.S30L	SIDM01147	Gastric Carcinoma	GDSC	DRSKLRSVS	DEG_APCC_DBOX_1	0.1111
p.S30L	ACH-000427	Gastric Cancer	CCLE	DRSKLRSVS	DEG_APCC_DBOX_1	0.1111
p.S30L	NCI-N87	stomach	COSMIC	DRSKLRSVS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5X3	Sorting nexin-5	DEG_APCC_DBOX_1	14:22	DRSKLRSVS	APC,CDC20,FZR1	0.8133	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons