DegronMD - Q9Y5X3(SNX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q11E	TCGA-CM-4743	COAD	TCGA	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.25
p.Q11E	DO8103	COAD	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.25
p.Q170H	TCGA-D3-A2JP	SKCM	TCGA	FHVFLE	LIG_APCC_ABBA_1	162:167	Mutation rewiring degron network	0.25
p.Q170H	DO47407	SKCM	ICGC	FHVFLE	LIG_APCC_ABBA_1	162:167	Mutation rewiring degron network	0.25
p.P154S	TCGA-FR-A7U9	SKCM	TCGA	FHVFLE	LIG_APCC_ABBA_1	162:167	Mutation rewiring degron network	0.1111
p.P154S	DO48546	SKCM	ICGC	FHVFLE	LIG_APCC_ABBA_1	162:167	Mutation rewiring degron network	0.1111
p.P5S	DO2593	BRCA	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0833
p.R176W	DO227849	COCA	ICGC	FHVFLE	LIG_APCC_ABBA_1	162:167	Mutation rewiring degron network	0.0833
p.N161D	DO233272	GACA	ICGC	FHVFLE	LIG_APCC_ABBA_1	162:167	Mutation rewiring degron network	0.3056
p.L18M	DO228974	LICA	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.711
p.E12Q	DO27120	LUSC	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2778
p.A21V	DO52682	MALY	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6936
p.E6D	DO52675	MALY	ICGC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.S30L	SIDM01147	Gastric Carcinoma	GDSC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.S30L	ACH-000427	Gastric Cancer	CCLE	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.S30L	NCI-N87	stomach	COSMIC	DRSKLRSVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.H163R	ACH-001610	Brain Cancer	CCLE	FHVFLE	LIG_APCC_ABBA_1	162:167	Mutation altering degron motif	0.7133

Kaplan plot for SNX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNX5

UniProt ID: Q9Y5X3

Entrez ID: 27131

Protein name: Sorting nexin-5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNX5 in