DegronMD

Uniprot ID: Q9Y5X3

Source protein: Sorting nexin-5

Source gene: SNX5

Class: LIG_APCC_ABBA_1

Location: 162:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5985

ASA_SCORE: 27.55

COIL: 0.137

CONS_SCORE: 0.6212

DSS_SCORE: 0.1235

HELIX: 0.09

FCONS_SCORE: 1.2498

RIG_SCORE: 0.8812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q170H	TCGA-D3-A2JP	SKCM	TCGA	FHVFLE	LIG_APCC_ABBA_1	0.25
p.Q170H	DO47407	SKCM	ICGC	FHVFLE	LIG_APCC_ABBA_1	0.25
p.P154S	TCGA-FR-A7U9	SKCM	TCGA	FHVFLE	LIG_APCC_ABBA_1	0.1111
p.P154S	DO48546	SKCM	ICGC	FHVFLE	LIG_APCC_ABBA_1	0.1111
p.R176W	DO227849	COCA	ICGC	FHVFLE	LIG_APCC_ABBA_1	0.0833
p.N161D	DO233272	GACA	ICGC	FHVFLE	LIG_APCC_ABBA_1	0.3056
p.H163R	ACH-001610	Brain Cancer	CCLE	FHVFLE	LIG_APCC_ABBA_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5X3	Sorting nexin-5	LIG_APCC_ABBA_1	162:167	FHVFLE	APC,CDC20,FZR1	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons