DegronMD

Uniprot ID: Q99675

Source protein: Cell growth regulator with RING finger domain protein 1

Source gene: CGRRF1

Class: DEG_APCC_DBOX_1

Location: 250:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9308

ASA_SCORE: 84.1111

COIL: 0.4056

CONS_SCORE: 0.5079

DSS_SCORE: 0.5947

HELIX: 0.5762

FCONS_SCORE: 1.0058

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S260P	TCGA-31-1959	OV	TCGA	DRSLLEKVG	DEG_APCC_DBOX_1	0.2778
p.S260P	DO28281	OV	ICGC	DRSLLEKVG	DEG_APCC_DBOX_1	0.2778
p.S260C	TCGA-CG-5717	STAD	TCGA	DRSLLEKVG	DEG_APCC_DBOX_1	0.2778
p.S260C	DO38272	STAD	ICGC	DRSLLEKVG	DEG_APCC_DBOX_1	0.2778
p.G258E	TCGA-IB-7651	PAAD	TCGA	DRSLLEKVG	DEG_APCC_DBOX_1	0.6087
p.G258E	DO46657	PAAD	ICGC	DRSLLEKVG	DEG_APCC_DBOX_1	0.6087
p.E245K	TCGA-MV-A51V	BLCA	TCGA	DRSLLEKVG	DEG_APCC_DBOX_1	0.1944
p.E245K	DO474	BLCA	ICGC	DRSLLEKVG	DEG_APCC_DBOX_1	0.1944
p.E268K	DO50970	LICA	ICGC	DRSLLEKVG	DEG_APCC_DBOX_1	0.0556
p.S267L	DO232761	PBCA	ICGC	DRSLLEKVG	DEG_APCC_DBOX_1	0.0833
p.S252G	SIDM00245	Small Cell Lung Carcinoma	GDSC	DRSLLEKVG	DEG_APCC_DBOX_1	0.6993
p.S252G	ACH-001131	Skin Cancer	CCLE	DRSLLEKVG	DEG_APCC_DBOX_1	0.6993
p.S252G	ACH-001958	lung	CCLE	DRSLLEKVG	DEG_APCC_DBOX_1	0.6993
p.S252G	MS-1	lung	COSMIC	DRSLLEKVG	DEG_APCC_DBOX_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99675	Cell growth regulator with RING finger domain protein 1	DEG_APCC_DBOX_1	250:258	DRSLLEKVG	APC,CDC20,FZR1	0.9308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons