DegronMD

Uniprot ID: Q8NBH2

Source protein: Kyphoscoliosis peptidase

Source gene: KY

Class: DEG_APCC_DBOX_1

Location: 138:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8443

ASA_SCORE: 75.8333

COIL: 0.6908

CONS_SCORE: 0.3871

DSS_SCORE: 0.374

HELIX: 0.2641

FCONS_SCORE: 0.9302

RIG_SCORE: 0.7492

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E153Q	TCGA-77-8136	LUSC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	0.1389
p.Q150K	TCGA-85-8071	LUSC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	0.2222
p.Q150K	TCGA-CD-5801	STAD	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	0.2222
p.S140Y	TCGA-AP-A059	UCEC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	0.6009
p.S144F	TCGA-AP-A1E0	UCEC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	0.7982
p.G129E	TCGA-D3-A3MU	SKCM	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	0.0833
p.K143T	TCGA-FA-A6HO	DLBC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	0.6195
p.K144N	DO51866	BLCA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.6918
p.Q129H	DO233098	GACA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.0833
p.Q140K	DO228976	LICA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.6944
p.Q140K	DO229027	LICA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.6944
p.Q129K	DO229027	LICA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.0833
p.Q129K	DO26755	LUSC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.0833
p.Q129K	DO38563	STAD	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.0833
p.E132Q	DO231043	LUSC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.1667
p.E132Q	DO26593	LUSC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.1667
p.E149K	DO220902	MELA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.25
p.E149K	DO219968	SARC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.25
p.Q140H	DO41999	UCEC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.7582
p.A143T	DO42408	UCEC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	0.7139
p.G128E	SIDM00487	Colorectal Carcinoma	GDSC	DRSSLKSMS	DEG_APCC_DBOX_1	0.0556
p.G128E	ACH-000963	Colon/Colorectal Cancer	CCLE	DRSSLKSMS	DEG_APCC_DBOX_1	0.0556
p.G128E	CCK-81	large_intestine	COSMIC	DRSSLKSMS	DEG_APCC_DBOX_1	0.0556
p.G129R	ACH-002005	Skin Cancer	CCLE	DRSSLKSMS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBH2	Kyphoscoliosis peptidase	DEG_APCC_DBOX_1	138:146	DRSSLKSMS	APC,CDC20,FZR1	0.8443	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons