DegronMD - Q8NBH2(KY)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R517Q	TCGA-06-0152	GBM	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation altering degron motif	0.6218
p.R517Q	TCGA-19-5956	GBM	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation altering degron motif	0.6218
p.E153Q	TCGA-77-8136	LUSC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1389
p.Q150K	TCGA-85-8071	LUSC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2222
p.Q150K	TCGA-CD-5801	STAD	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.2222
p.Q508P	TCGA-A6-6653	COAD	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.1944
p.S140Y	TCGA-AP-A059	UCEC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6009
p.R509W	TCGA-AP-A0LM	UCEC	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.2222
p.R509W	SIDM00429	B-Lymphoblastic Leukemia	GDSC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.2222
p.R509W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.2222
p.S144F	TCGA-AP-A1E0	UCEC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.7982
p.R510C	TCGA-BG-A18B	UCEC	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.25
p.R510C	TCGA-FI-A2D5	UCEC	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.25
p.R509L	TCGA-D3-A3C6	SKCM	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.2222
p.G129E	TCGA-D3-A3MU	SKCM	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0833
p.K143T	TCGA-FA-A6HO	DLBC	TCGA	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6195
p.R510H	TCGA-VQ-A94R	STAD	TCGA	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.25
p.R510H	SIDM00376	B-Lymphoblastic Leukemia	GDSC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.25
p.K144N	DO51866	BLCA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6918
p.K520N	DO6329	CESC	ICGC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.2778
p.Q129H	DO233098	GACA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0833
p.Q140K	DO228976	LICA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6944
p.Q140K	DO229027	LICA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.6944
p.Q129K	DO229027	LICA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0833
p.Q129K	DO26755	LUSC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0833
p.Q129K	DO38563	STAD	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0833
p.K515N	DO23690	LUAD	ICGC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation altering degron motif	0.6918
p.E132Q	DO231043	LUSC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1667
p.E132Q	DO26593	LUSC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.1667
p.E149K	DO220902	MELA	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.25
p.E149K	DO219968	SARC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.25
p.E523K	DO48667	SKCM	ICGC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.1944
p.K511R	DO51795	STAD	ICGC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation rewiring degron network	0.2778
p.Q140H	DO41999	UCEC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.7582
p.A143T	DO42408	UCEC	ICGC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation altering degron motif	0.7139
p.G128E	SIDM00487	Colorectal Carcinoma	GDSC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0556
p.G128E	ACH-000963	Colon/Colorectal Cancer	CCLE	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0556
p.G128E	CCK-81	large intestine	COSMIC	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0556
p.G129R	ACH-002005	Skin Cancer	CCLE	DRSSLKSMS	DEG_APCC_DBOX_1	138:146	Mutation rewiring degron network	0.0833
p.F517I	ESO51	oesophagus	COSMIC	FQLHRE	LIG_APCC_ABBA_1	513:518	Mutation altering degron motif	0.7415

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KY

UniProt ID: Q8NBH2

Entrez ID: 339855

Protein name: Kyphoscoliosis peptidase (EC 3.4.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KY in