DegronMD

Uniprot ID: Q8NBH2

Source protein: Kyphoscoliosis peptidase

Source gene: KY

Class: LIG_APCC_ABBA_1

Location: 513:518

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5015

ASA_SCORE: 80.0833

COIL: 0.2272

CONS_SCORE: 0.2989

DSS_SCORE: 0.3122

HELIX: 0.0028

FCONS_SCORE: 0.7057

RIG_SCORE: 0.8417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R517Q	TCGA-06-0152	GBM	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.6218
p.R517Q	TCGA-19-5956	GBM	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.6218
p.Q508P	TCGA-A6-6653	COAD	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.1944
p.R509W	TCGA-AP-A0LM	UCEC	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.2222
p.R509W	SIDM00429	B-Lymphoblastic Leukemia	GDSC	FQLHRE	LIG_APCC_ABBA_1	0.2222
p.R509W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	FQLHRE	LIG_APCC_ABBA_1	0.2222
p.R510C	TCGA-BG-A18B	UCEC	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.25
p.R510C	TCGA-FI-A2D5	UCEC	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.25
p.R509L	TCGA-D3-A3C6	SKCM	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.2222
p.R510H	TCGA-VQ-A94R	STAD	TCGA	FQLHRE	LIG_APCC_ABBA_1	0.25
p.R510H	SIDM00376	B-Lymphoblastic Leukemia	GDSC	FQLHRE	LIG_APCC_ABBA_1	0.25
p.K520N	DO6329	CESC	ICGC	FQLHRE	LIG_APCC_ABBA_1	0.2778
p.K515N	DO23690	LUAD	ICGC	FQLHRE	LIG_APCC_ABBA_1	0.6918
p.E523K	DO48667	SKCM	ICGC	FQLHRE	LIG_APCC_ABBA_1	0.1944
p.K511R	DO51795	STAD	ICGC	FQLHRE	LIG_APCC_ABBA_1	0.2778
p.F517I	ESO51	oesophagus	COSMIC	FQLHRE	LIG_APCC_ABBA_1	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBH2	Kyphoscoliosis peptidase	LIG_APCC_ABBA_1	513:518	FQLHRE	APC,CDC20,FZR1	0.5015	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons