DegronMD

Uniprot ID: Q3LXA3

Source protein: Triokinase/FMN cyclase

Source gene: TKFC

Class: DEG_APCC_DBOX_1

Location: 492:500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6077

ASA_SCORE: 26.0444

COIL: 0.2816

CONS_SCORE: 0.5771

DSS_SCORE: 0.313

HELIX: 0.48

FCONS_SCORE: 1.4824

RIG_SCORE: 0.8059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A488V	SIDM00781	Colorectal Carcinoma	GDSC	DRTMLDSLW	DEG_APCC_DBOX_1	0.2222
p.A488V	SIDM00780	Colorectal Carcinoma	GDSC	DRTMLDSLW	DEG_APCC_DBOX_1	0.2222
p.A488V	SNU-C2B	large_intestine	COSMIC	DRTMLDSLW	DEG_APCC_DBOX_1	0.2222
p.A502V	SIDM00673	Breast Carcinoma	GDSC	DRTMLDSLW	DEG_APCC_DBOX_1	0.2778
p.A502V	HCC70	breast	COSMIC	DRTMLDSLW	DEG_APCC_DBOX_1	0.2778
p.R493G	SIDM01727	Chronic Myelogenous Leukemia	GDSC	DRTMLDSLW	DEG_APCC_DBOX_1	0.7568
p.R493G	SIDM00173	Head and Neck Carcinoma	GDSC	DRTMLDSLW	DEG_APCC_DBOX_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3LXA3	Triokinase/FMN cyclase	DEG_APCC_DBOX_1	492:500	DRTMLDSLW	APC,CDC20,FZR1	0.6077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons