DegronMD

Uniprot ID: Q6ZS11

Source protein: Ras and Rab interactor-like protein

Source gene: RINL

Class: DEG_APCC_DBOX_1

Location: 27:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9946

ASA_SCORE: 72.8889

COIL: 0.8631

CONS_SCORE: 0.7288

DSS_SCORE: 0.4219

HELIX: 0.0591

FCONS_SCORE: 0.9091

RIG_SCORE: 0.7814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N24D	DO230334	COCA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.25
p.N24D	DO229010	COCA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.25
p.N24D	DO229013	COCA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.25
p.N24D	DO229016	COCA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.25
p.N24D	DO229003	COCA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.25
p.N24D	DO229005	COCA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.25
p.V17I	DO230342	COCA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.0556
p.R42H	DO233855	GACA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.1389
p.E34A	DO18899	KIRC	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.7701
p.A26E	DO229037	LICA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.3056
p.P19T	DO229041	LICA	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.1111
p.H35N	DO26949	LUSC	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.7423
p.D37N	DO47569	SKCM	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.2778
p.L18M	DO41572	UCEC	ICGC	DRTPLGVLS	DEG_APCC_DBOX_1	0.0833
p.R42C	ACH-000986	Colon/Colorectal Cancer	CCLE	DRTPLGVLS	DEG_APCC_DBOX_1	0.1389
p.P26S	HuP-T3	pancreas	COSMIC	DRTPLGVLS	DEG_APCC_DBOX_1	0.3056
p.D37G	CW-2	large_intestine	COSMIC	DRTPLGVLS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZS11	Ras and Rab interactor-like protein	DEG_APCC_DBOX_1	27:35	DRTPLGVLS	APC,CDC20,FZR1	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons