DegronMD

Uniprot ID: Q7Z401

Source protein: C-myc promoter-binding protein

Source gene: DENND4A

Class: DEG_APCC_DBOX_1

Location: 1354:1362

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9948

ASA_SCORE: 65.1667

COIL: 0.8093

CONS_SCORE: 0.2933

DSS_SCORE: 0.5849

HELIX: 0.1313

FCONS_SCORE: 1.0359

RIG_SCORE: 0.6448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1348P	TCGA-AJ-A3EL	UCEC	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	0.1667
p.S1348P	DO41542	UCEC	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	0.1667
p.D1352H	TCGA-DK-A3IS	BLCA	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	0.2778
p.D1352H	DO566	BLCA	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	0.2778
p.V1361A	TCGA-EE-A29H	SKCM	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	0.6936
p.K1358T	TCGA-FU-A3HZ	CESC	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	0.7306
p.F1367L	TCGA-GN-A26A	SKCM	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	0.1944
p.P1357T	DO229035	LICA	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	0.7031
p.T1356N	DO229045	LICA	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	0.5944
p.S1359C	DO25867	LUAD	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	0.643
p.S1359C	ACH-000500	Head and Neck Cancer	CCLE	DRTSLSSVG	DEG_APCC_DBOX_1	0.643
p.R1355C	DO37406	SKCM	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	0.8301
p.R1355C	DO50301	SKCM	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	0.8301
p.R1355C	ACH-000953	Leukemia	CCLE	DRTSLSSVG	DEG_APCC_DBOX_1	0.8301
p.R1355C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DRTSLSSVG	DEG_APCC_DBOX_1	0.8301
p.H1344Y	SIDM00206	Glioblastoma	GDSC	DRTSLSSVG	DEG_APCC_DBOX_1	0.5
p.H1344Y	SIDM00836	Colorectal Carcinoma	GDSC	DRTSLSSVG	DEG_APCC_DBOX_1	0.5
p.L1359I	SIDM00893	Breast Carcinoma	GDSC	DRTSLSSVG	DEG_APCC_DBOX_1	0.7174
p.L1359I	BT-20	breast	COSMIC	DRTSLSSVG	DEG_APCC_DBOX_1	0.7174
p.L1360I	BT-20	breast	COSMIC	DRTSLSSVG	DEG_APCC_DBOX_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z401	C-myc promoter-binding protein	DEG_APCC_DBOX_1	1354:1362	DRTSLSSVG	APC,CDC20,FZR1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons