DegronMD - Q7Z401(DENND4A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1402C	TCGA-91-6830	LUAD	TCGA	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.7541
p.S1402C	SIDM01448	Head and Neck Carcinoma	GDSC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.7541
p.S1348P	TCGA-AJ-A3EL	UCEC	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation rewiring degron network	0.1667
p.S1348P	DO41542	UCEC	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation rewiring degron network	0.1667
p.D1352H	TCGA-DK-A3IS	BLCA	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation rewiring degron network	0.2778
p.D1352H	DO566	BLCA	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation rewiring degron network	0.2778
p.V1361A	TCGA-EE-A29H	SKCM	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.6936
p.R1398C	TCGA-FR-A8YC	SKCM	TCGA	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.8301
p.R1398C	TCGA-FW-A3R5	SKCM	TCGA	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.8301
p.R1398C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.8301
p.R1398C	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.8301
p.K1358T	TCGA-FU-A3HZ	CESC	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.7306
p.F1367L	TCGA-GN-A26A	SKCM	TCGA	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation rewiring degron network	0.1944
p.S1408P	DO8264	COAD	ICGC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation rewiring degron network	0.2222
p.S1401R	DO229028	LICA	ICGC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.6316
p.P1357T	DO229035	LICA	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.7031
p.T1356N	DO229045	LICA	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.5944
p.S1359C	DO25867	LUAD	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.643
p.S1359C	ACH-000500	Head and Neck Cancer	CCLE	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.643
p.R1355C	DO37406	SKCM	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.8301
p.R1355C	DO50301	SKCM	ICGC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.8301
p.R1355C	ACH-000953	Leukemia	CCLE	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.8301
p.R1355C	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.8301
p.R1397I	DO47769	STAD	ICGC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.8102
p.H1344Y	SIDM00206	Glioblastoma	GDSC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation blocking phosphorylation signal	0.5
p.H1344Y	SIDM00836	Colorectal Carcinoma	GDSC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation blocking phosphorylation signal	0.5
p.L1359I	SIDM00893	Breast Carcinoma	GDSC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.7174
p.L1359I	BT-20	breast	COSMIC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.7174
p.R1402Q	ACH-000090	Prostate Cancer	CCLE	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.6218
p.R1402Q	PC-3	prostate	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.6218
p.S1390R	ACH-000383	Esophageal Cancer	CCLE	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation rewiring degron network	0.1667
p.S1390R	OE33	oesophagus	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation rewiring degron network	0.1667
p.S1414Y	ACH-000986	Colon/Colorectal Cancer	CCLE	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation rewiring degron network	0.0556
p.S1414Y	HT-115	large intestine	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation rewiring degron network	0.0556
p.L1360I	BT-20	breast	COSMIC	DRTSLSSVG	DEG_APCC_DBOX_1	1354:1362	Mutation altering degron motif	0.7174
p.R1399C	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	1396:1404	Mutation altering degron motif	0.8301

Kaplan plot for DENND4A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND4A

UniProt ID: Q7Z401

Entrez ID: 10260

Protein name: C-myc promoter-binding protein (DENN domain-containing protein 4A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DENND4A in