DegronMD

Uniprot ID: Q7Z401

Source protein: C-myc promoter-binding protein

Source gene: DENND4A

Class: DEG_APCC_DBOX_1

Location: 1396:1404

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.63

ASA_SCORE: 86.7778

COIL: 0.6509

CONS_SCORE: 0.2785

DSS_SCORE: 0.4155

HELIX: 0.2704

FCONS_SCORE: 0.9429

RIG_SCORE: 0.7768

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1398C	TCGA-FR-A8YC	SKCM	TCGA	KRIDLSRIS	DEG_APCC_DBOX_1	0.8301
p.R1398C	TCGA-FW-A3R5	SKCM	TCGA	KRIDLSRIS	DEG_APCC_DBOX_1	0.8301
p.R1398C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KRIDLSRIS	DEG_APCC_DBOX_1	0.8301
p.R1398C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	0.8301
p.R1399C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	0.8301
p.R1397I	DO47769	STAD	ICGC	KRIDLSRIS	DEG_APCC_DBOX_1	0.8102
p.S1402C	TCGA-91-6830	LUAD	TCGA	KRIDLSRIS	DEG_APCC_DBOX_1	0.7541
p.S1402C	SIDM01448	Head and Neck Carcinoma	GDSC	KRIDLSRIS	DEG_APCC_DBOX_1	0.7541
p.S1401R	DO229028	LICA	ICGC	KRIDLSRIS	DEG_APCC_DBOX_1	0.6316
p.R1402Q	ACH-000090	Prostate Cancer	CCLE	KRIDLSRIS	DEG_APCC_DBOX_1	0.6218
p.R1402Q	PC-3	prostate	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	0.6218
p.S1408P	DO8264	COAD	ICGC	KRIDLSRIS	DEG_APCC_DBOX_1	0.2222
p.S1390R	ACH-000383	Esophageal Cancer	CCLE	KRIDLSRIS	DEG_APCC_DBOX_1	0.1667
p.S1390R	OE33	oesophagus	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	0.1667
p.S1414Y	ACH-000986	Colon/Colorectal Cancer	CCLE	KRIDLSRIS	DEG_APCC_DBOX_1	0.0556
p.S1414Y	HT-115	large_intestine	COSMIC	KRIDLSRIS	DEG_APCC_DBOX_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z401	C-myc promoter-binding protein	DEG_APCC_DBOX_1	1396:1404	KRIDLSRIS	APC,CDC20,FZR1	0.63	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons