DegronMD

Uniprot ID: Q9C0J8

Source protein: pre-mRNA 3' end processing protein WDR33

Source gene: WDR33

Class: DEG_APCC_DBOX_1

Location: 413:421

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6129

ASA_SCORE: 79.1444

COIL: 0.6639

CONS_SCORE: 0.4332

DSS_SCORE: 0.4509

HELIX: 0.2199

FCONS_SCORE: 0.9392

RIG_SCORE: 0.7782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M411V	TCGA-BR-4362	STAD	TCGA	DRYNLNLLP	DEG_APCC_DBOX_1	0.2778
p.M411V	DO38336	STAD	ICGC	DRYNLNLLP	DEG_APCC_DBOX_1	0.2778
p.R406Q	TCGA-CG-4460	STAD	TCGA	DRYNLNLLP	DEG_APCC_DBOX_1	0.1389
p.R406Q	DO38427	STAD	ICGC	DRYNLNLLP	DEG_APCC_DBOX_1	0.1389
p.R404Q	TCGA-EE-A2MS	SKCM	TCGA	DRYNLNLLP	DEG_APCC_DBOX_1	0.0833
p.R404Q	DO37567	SKCM	ICGC	DRYNLNLLP	DEG_APCC_DBOX_1	0.0833
p.G427R	TCGA-HD-7832	HNSC	TCGA	DRYNLNLLP	DEG_APCC_DBOX_1	0.1667
p.G427R	DO16061	HNSC	ICGC	DRYNLNLLP	DEG_APCC_DBOX_1	0.1667
p.D431G	DO228636	PRAD	ICGC	DRYNLNLLP	DEG_APCC_DBOX_1	0.0556
p.R414Q	SIDM00238	Ovarian Carcinoma	GDSC	DRYNLNLLP	DEG_APCC_DBOX_1	0.7329
p.R414Q	ACH-000947	Ovarian Cancer	CCLE	DRYNLNLLP	DEG_APCC_DBOX_1	0.7329
p.R414Q	OVK-18	ovary	COSMIC	DRYNLNLLP	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0J8	pre-mRNA 3' end processing protein WDR33	DEG_APCC_DBOX_1	413:421	DRYNLNLLP	APC,CDC20,FZR1	0.6129	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons