DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DRYPLYVIP
Uniprot ID:
Q8TE99
Source protein:
2-phosphoxylose phosphatase 1
Source gene:
PXYLP1
Class:
DEG_APCC_DBOX_1
Location:
99:107
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5359
ASA_SCORE:
33.8667
COIL:
0.778
CONS_SCORE:
0.5015
DSS_SCORE:
0.2021
HELIX:
0.0947
FCONS_SCORE:
1.0222
RIG_SCORE:
0.8392
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H92Y
SIDM00534
Colorectal Carcinoma
GDSC
DRYPLYVIP
DEG_APCC_DBOX_1
0.1389
p.H92Y
HT-115
large_intestine
COSMIC
DRYPLYVIP
DEG_APCC_DBOX_1
0.1389
Drug responses associated with PXYLP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DRYPLYVIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TE99
2-phosphoxylose phosphatase 1
DEG_APCC_DBOX_1
99:107
DRYPLYVIP
APC,CDC20,FZR1
0.5359
More...