DegronMD

Uniprot ID: P43268

Source protein: ETS translocation variant 4

Source gene: ETV4

Class: DEG_COP1_1

Location: 72:81

E3 ligase: COP1

DEGRON score: 0.9994

ASA_SCORE: 75.27

COIL: 0.7927

CONS_SCORE: 0.4878

DSS_SCORE: 0.5538

HELIX: 0.1347

FCONS_SCORE: 1.0351

RIG_SCORE: 0.7244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D72N	TCGA-17-Z026	LUAD	TCGA	DSDEQFVPDF	DEG_COP1_1	0.6932
p.D72N	TCGA-XF-A9T6	BLCA	TCGA	DSDEQFVPDF	DEG_COP1_1	0.6932
p.Q69H	TCGA-A5-A0G2	UCEC	TCGA	DSDEQFVPDF	DEG_COP1_1	0.25
p.D80A	TCGA-A5-A1OF	UCEC	TCGA	DSDEQFVPDF	DEG_COP1_1	0.7793
p.R64H	DO9010	COAD	ICGC	DSDEQFVPDF	DEG_COP1_1	0.1111
p.S70Y	DO229025	LICA	ICGC	DSDEQFVPDF	DEG_COP1_1	0.2778
p.P63H	DO229026	LICA	ICGC	DSDEQFVPDF	DEG_COP1_1	0.0833
p.A68V	DO50970	LICA	ICGC	DSDEQFVPDF	DEG_COP1_1	0.2222
p.S89I	DO46372	OV	ICGC	DSDEQFVPDF	DEG_COP1_1	0.1111
p.P76Q	DO37595	SKCM	ICGC	DSDEQFVPDF	DEG_COP1_1	0.7035
p.C85Y	DO47849	STAD	ICGC	DSDEQFVPDF	DEG_COP1_1	0.2222
p.E83K	DO43714	UCEC	ICGC	DSDEQFVPDF	DEG_COP1_1	0.2778
p.D74N	SIDM02021	Esophageal Carcinoma	GDSC	DSDEQFVPDF	DEG_COP1_1	0.5821
p.T63M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSDEQFVPDF	DEG_COP1_1	0.0833
p.T63M	ACH-002256	Leukemia	CCLE	DSDEQFVPDF	DEG_COP1_1	0.0833
p.T63M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSDEQFVPDF	DEG_COP1_1	0.0833
p.H81N	SNU-407	large_intestine	COSMIC	DSDEQFVPDF	DEG_COP1_1	0.7423
p.P78S	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	DSDEQFVPDF	DEG_COP1_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons