DegronMD - P43268(ETV4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D72N	TCGA-17-Z026	LUAD	TCGA	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation altering degron motif	0.6932
p.D72N	TCGA-XF-A9T6	BLCA	TCGA	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation altering degron motif	0.6932
p.P305S	TCGA-2W-A8YY	CESC	TCGA	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.6752
p.Q69H	TCGA-A5-A0G2	UCEC	TCGA	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.25
p.D80A	TCGA-A5-A1OF	UCEC	TCGA	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation altering degron motif	0.7793
p.E300D	TCGA-D1-A16X	UCEC	TCGA	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.25
p.V312L	TCGA-D3-A1QB	SKCM	TCGA	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.F317S	TCGA-EO-A22R	UCEC	TCGA	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0833
p.V310F	TCGA-Z2-AA3S	SKCM	TCGA	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2778
p.R299W	DO223732	CESC	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.R299W	DO47925	STAD	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.R299W	SNU-1040	large intestine	COSMIC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.R64H	DO9010	COAD	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.1111
p.R298H	DO233652	GACA	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1944
p.L302P	DO11166	GBM	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.3056
p.Q306K	DO229015	LICA	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.6944
p.A318D	DO229022	LICA	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0556
p.S70Y	DO229025	LICA	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.2778
p.P63H	DO229026	LICA	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.0833
p.A68V	DO50970	LICA	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.2222
p.S89I	DO46372	OV	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.1111
p.P76Q	DO37595	SKCM	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation altering degron motif	0.7035
p.V273L	DO47573	SKCM	ICGC	MYLHTE	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1944
p.V271F	DO51302	SKCM	ICGC	MYLHTE	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1389
p.R298C	DO50118	STAD	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1944
p.C85Y	DO47849	STAD	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.2222
p.F307Y	DO43290	UCEC	ICGC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.7528
p.E83K	DO43714	UCEC	ICGC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.2778
p.F278S	DO42713	UCEC	ICGC	MYLHTE	LIG_APCC_ABBA_1	278:283	Mutation altering degron motif	0.7982
p.D74N	SIDM02021	Esophageal Carcinoma	GDSC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation altering degron motif	0.5821
p.V312I	SIDM00845	Burkitt's Lymphoma	GDSC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.V312I	SIDM01519	Head and Neck Carcinoma	GDSC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.T63M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.0833
p.T63M	ACH-002256	Leukemia	CCLE	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.0833
p.T63M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation rewiring degron network	0.0833
p.V310I	SIDM01617	Endometrial Carcinoma	GDSC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2778
p.H304N	ACH-000955	Colon/Colorectal Cancer	CCLE	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.7423
p.H304N	SNU-407	large intestine	COSMIC	LRPFPD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.7423
p.R284W	ACH-000999	Colon/Colorectal Cancer	CCLE	MYLHTE	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.3056
p.R284W	SNU-1040	large intestine	COSMIC	MYLHTE	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.3056
p.T273I	ACH-001127	Leukemia	CCLE	MYLHTE	LIG_APCC_ABBA_1	278:283	Mutation rewiring degron network	0.1944
p.H81N	SNU-407	large intestine	COSMIC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation altering degron motif	0.7423
p.D281G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	MYLHTE	LIG_APCC_ABBA_1	278:283	Mutation altering degron motif	0.7198
p.P78S	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	DSDEQFVPDF	DEG_COP1_1	72:81	Mutation altering degron motif	0.6752

Kaplan plot for ETV4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETV4

UniProt ID: P43268

Entrez ID: 2118

Protein name: ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETV4 in