DegronMD

Uniprot ID: P43268

Source protein: ETS translocation variant 4

Source gene: ETV4

Class: LIG_APCC_ABBA_1

Location: 303:308

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9923

ASA_SCORE: 80.9333

COIL: 0.8772

CONS_SCORE: 0.4965

DSS_SCORE: 0.3484

HELIX: 0.0557

FCONS_SCORE: 1.1188

RIG_SCORE: 0.7689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P305S	TCGA-2W-A8YY	CESC	TCGA	LRPFPD	LIG_APCC_ABBA_1	0.6752
p.E300D	TCGA-D1-A16X	UCEC	TCGA	LRPFPD	LIG_APCC_ABBA_1	0.25
p.V312L	TCGA-D3-A1QB	SKCM	TCGA	LRPFPD	LIG_APCC_ABBA_1	0.2222
p.F317S	TCGA-EO-A22R	UCEC	TCGA	LRPFPD	LIG_APCC_ABBA_1	0.0833
p.V310F	TCGA-Z2-AA3S	SKCM	TCGA	LRPFPD	LIG_APCC_ABBA_1	0.2778
p.R299W	DO223732	CESC	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.2222
p.R299W	DO47925	STAD	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.2222
p.R299W	SNU-1040	large_intestine	COSMIC	LRPFPD	LIG_APCC_ABBA_1	0.2222
p.R298H	DO233652	GACA	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.1944
p.L302P	DO11166	GBM	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.3056
p.Q306K	DO229015	LICA	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.6944
p.A318D	DO229022	LICA	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.0556
p.R298C	DO50118	STAD	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.1944
p.F307Y	DO43290	UCEC	ICGC	LRPFPD	LIG_APCC_ABBA_1	0.7528
p.V312I	SIDM00845	Burkitt's Lymphoma	GDSC	LRPFPD	LIG_APCC_ABBA_1	0.2222
p.V312I	SIDM01519	Head and Neck Carcinoma	GDSC	LRPFPD	LIG_APCC_ABBA_1	0.2222
p.V310I	SIDM01617	Endometrial Carcinoma	GDSC	LRPFPD	LIG_APCC_ABBA_1	0.2778
p.H304N	ACH-000955	Colon/Colorectal Cancer	CCLE	LRPFPD	LIG_APCC_ABBA_1	0.7423
p.H304N	SNU-407	large_intestine	COSMIC	LRPFPD	LIG_APCC_ABBA_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43268	ETS translocation variant 4	LIG_APCC_ABBA_1	303:308	LRPFPD	APC,CDC20,FZR1	0.9923	More...
Q96M15	Putative uncharacterized protein IGF2BP2-AS1	LIG_APCC_ABBA_1	9:14	LRPFPD	APC,CDC20,FZR1	0.6215	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons