DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LRPFPD
Uniprot ID:
Q96M15
Source protein:
Putative uncharacterized protein IGF2BP2-AS1
Source gene:
IGF2BP2-AS1
Class:
LIG_APCC_ABBA_1
Location:
9:14
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6215
ASA_SCORE:
67.7167
COIL:
0.764
CONS_SCORE:
0
DSS_SCORE:
0.3918
HELIX:
0.0483
FCONS_SCORE:
0
RIG_SCORE:
0.7781
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with IGF2BP2-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRPFPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P43268
ETS translocation variant 4
LIG_APCC_ABBA_1
303:308
LRPFPD
APC,CDC20,FZR1
0.9923
More...
Q96M15
Putative uncharacterized protein IGF2BP2-AS1
LIG_APCC_ABBA_1
9:14
LRPFPD
APC,CDC20,FZR1
0.6215
More...