DegronMD

Uniprot ID: P43268

Source protein: ETS translocation variant 4

Source gene: ETV4

Class: LIG_APCC_ABBA_1

Location: 278:283

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8853

ASA_SCORE: 58.85

COIL: 0.7293

CONS_SCORE: 0.3288

DSS_SCORE: 0.3702

HELIX: 0.0992

FCONS_SCORE: 0.8588

RIG_SCORE: 0.774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V273L	DO47573	SKCM	ICGC	MYLHTE	LIG_APCC_ABBA_1	0.1944
p.V271F	DO51302	SKCM	ICGC	MYLHTE	LIG_APCC_ABBA_1	0.1389
p.F278S	DO42713	UCEC	ICGC	MYLHTE	LIG_APCC_ABBA_1	0.7982
p.R284W	ACH-000999	Colon/Colorectal Cancer	CCLE	MYLHTE	LIG_APCC_ABBA_1	0.3056
p.R284W	SNU-1040	large_intestine	COSMIC	MYLHTE	LIG_APCC_ABBA_1	0.3056
p.T273I	ACH-001127	Leukemia	CCLE	MYLHTE	LIG_APCC_ABBA_1	0.1944
p.D281G	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	MYLHTE	LIG_APCC_ABBA_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43268	ETS translocation variant 4	LIG_APCC_ABBA_1	278:283	MYLHTE	APC,CDC20,FZR1	0.8853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons