DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSDSGE
Uniprot ID:
Q5GJ75
Source protein:
Tumor necrosis factor alpha-induced protein 8-like protein 3
Source gene:
TNFAIP8L3
Class:
DEG_Kelch_Keap1_1
Location:
90:95
E3 ligase:
KEAP1
DEGRON score:
0.6893
ASA_SCORE:
92.9667
COIL:
0.8932
CONS_SCORE:
0.3033
DSS_SCORE:
0.7645
HELIX:
0.0903
FCONS_SCORE:
1.0016
RIG_SCORE:
0.5608
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D92N
DO232051
ORCA
ICGC
DSDSGE
DEG_Kelch_Keap1_1
0.6932
p.T103S
SIDM00855
Other Sarcomas
GDSC
DSDSGE
DEG_Kelch_Keap1_1
0.5556
Drug responses associated with TNFAIP8L3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSDSGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5GJ75
Tumor necrosis factor alpha-induced protein 8-like protein 3
DEG_Kelch_Keap1_1
90:95
DSDSGE
KEAP1
0.6893
More...