DegronMD

Uniprot ID: Q9BPX3

Source protein: Condensin complex subunit 3

Source gene: NCAPG

Class: DEG_COP1_1

Location: 972:982

E3 ligase: COP1

DEGRON score: 0.9872

ASA_SCORE: 101.3727

COIL: 0.8826

CONS_SCORE: 0.2909

DSS_SCORE: 0.6861

HELIX: 0.1133

FCONS_SCORE: 1.1371

RIG_SCORE: 0.6161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D972N	TCGA-A5-A0G2	UCEC	TCGA	DSESDHEVPEP	DEG_COP1_1	0.6932
p.D972N	DO41235	UCEC	ICGC	DSESDHEVPEP	DEG_COP1_1	0.6932
p.D972N	ACH-002048	Sarcoma	CCLE	DSESDHEVPEP	DEG_COP1_1	0.6932
p.R989K	TCGA-AX-A06F	UCEC	TCGA	DSESDHEVPEP	DEG_COP1_1	0.1389
p.R989K	DO41752	UCEC	ICGC	DSESDHEVPEP	DEG_COP1_1	0.1389
p.E970D	TCGA-CA-6717	COAD	TCGA	DSESDHEVPEP	DEG_COP1_1	0.2778
p.E970D	DO8264	COAD	ICGC	DSESDHEVPEP	DEG_COP1_1	0.2778
p.T968I	TCGA-CS-6188	LGG	TCGA	DSESDHEVPEP	DEG_COP1_1	0.6667
p.T968I	DO22115	LGG	ICGC	DSESDHEVPEP	DEG_COP1_1	0.6667
p.M988I	TCGA-D5-6535	COAD	TCGA	DSESDHEVPEP	DEG_COP1_1	0.1667
p.M988I	DO10397	COAD	ICGC	DSESDHEVPEP	DEG_COP1_1	0.1667
p.Q967H	TCGA-D5-6930	COAD	TCGA	DSESDHEVPEP	DEG_COP1_1	0.1944
p.Q967H	DO10550	COAD	ICGC	DSESDHEVPEP	DEG_COP1_1	0.1944
p.T962P	TCGA-GS-A9TZ	DLBC	TCGA	DSESDHEVPEP	DEG_COP1_1	0.0556
p.T962P	DO219918	DLBC	ICGC	DSESDHEVPEP	DEG_COP1_1	0.0556
p.R965M	DO229009	LICA	ICGC	DSESDHEVPEP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BPX3	Condensin complex subunit 3	DEG_COP1_1	972:982	DSESDHEVPEP	COP1	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons