DegronMD

Uniprot ID: O75912

Source protein: Diacylglycerol kinase iota

Source gene: DGKI

Class: DEG_Kelch_Keap1_1

Location: 991:996

E3 ligase: KEAP1

DEGRON score: 0.5979

ASA_SCORE: 72.7667

COIL: 0.7703

CONS_SCORE: 0.4406

DSS_SCORE: 0.3661

HELIX: 0.1818

FCONS_SCORE: 1.0716

RIG_SCORE: 0.7145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T997P	TCGA-BR-A4PE	STAD	TCGA	DSETGE	DEG_Kelch_Keap1_1	0.3056
p.E985K	TCGA-CA-6718	COAD	TCGA	DSETGE	DEG_Kelch_Keap1_1	0.1667
p.E985K	ACH-002039	Pancreatic Cancer	CCLE	DSETGE	DEG_Kelch_Keap1_1	0.1667
p.A1002T	TCGA-FR-A726	SKCM	TCGA	DSETGE	DEG_Kelch_Keap1_1	0.1667
p.G995C	TCGA-FS-A1ZB	SKCM	TCGA	DSETGE	DEG_Kelch_Keap1_1	0.76
p.D988N	TCGA-O2-A52S	LUSC	TCGA	DSETGE	DEG_Kelch_Keap1_1	0.25
p.D998E	DO223702	COAD	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.2778
p.R990L	DO219887	DLBC	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.3056
p.A1003E	DO229036	LICA	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.1389
p.Q994H	DO52182	LIHC	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.7582
p.N989K	DO23907	LUAD	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.2778
p.G1000R	DO45540	LUSC	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.2222
p.R990H	DO222837	MELA	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.3056
p.R988Q	DO230637	PRAD	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.25
p.A984T	DO48665	SKCM	ICGC	DSETGE	DEG_Kelch_Keap1_1	0.1389
p.E996D	SIDM00472	Ovarian Carcinoma	GDSC	DSETGE	DEG_Kelch_Keap1_1	0.6758
p.E996D	ACH-001630	Ovarian Cancer	CCLE	DSETGE	DEG_Kelch_Keap1_1	0.6758
p.E996D	PEO1	ovary	COSMIC	DSETGE	DEG_Kelch_Keap1_1	0.6758
p.H981R	SIDM00720	Mesothelioma	GDSC	DSETGE	DEG_Kelch_Keap1_1	0.0556
p.H981R	NCI-H28	pleura	COSMIC	DSETGE	DEG_Kelch_Keap1_1	0.0556
p.A999V	SNU-1040	large_intestine	COSMIC	DSETGE	DEG_Kelch_Keap1_1	0.25
p.H994R	NCI-H28	pleura	COSMIC	DSETGE	DEG_Kelch_Keap1_1	0.8244
p.G985R	LB996-RCC	kidney	COSMIC	DSETGE	DEG_Kelch_Keap1_1	0.1667
p.A1001V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSETGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75912	Diacylglycerol kinase iota	DEG_Kelch_Keap1_1	991:996	DSETGE	KEAP1	0.5979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons