DegronMD - O75912(DGKI)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L486R	TCGA-22-4605	LUSC	TCGA	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1944
p.L486R	DO27232	LUSC	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1944
p.P481H	TCGA-22-5472	LUSC	TCGA	NWGGGYTDEP	CBL_PTK	472:481	Mutation altering degron motif	0.7694
p.P481H	TCGA-D3-A3C8	SKCM	TCGA	NWGGGYTDEP	CBL_PTK	472:481	Mutation altering degron motif	0.7694
p.P481H	DO27421	LUSC	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation altering degron motif	0.7694
p.P481H	DO47636	SKCM	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation altering degron motif	0.7694
p.E480K	TCGA-AP-A0LM	UCEC	TCGA	NWGGGYTDEP	CBL_PTK	472:481	Mutation altering degron motif	0.591
p.E480K	DO43306	UCEC	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation altering degron motif	0.591
p.T997P	TCGA-BR-A4PE	STAD	TCGA	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.3056
p.E985K	TCGA-CA-6718	COAD	TCGA	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.1667
p.E985K	ACH-002039	Pancreatic Cancer	CCLE	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.1667
p.R469Q	TCGA-D3-A51T	SKCM	TCGA	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.25
p.R469Q	DO47389	SKCM	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.25
p.L467M	TCGA-DK-A3IL	BLCA	TCGA	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1944
p.L467M	DO555	BLCA	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1944
p.A1002T	TCGA-FR-A726	SKCM	TCGA	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.1667
p.G995C	TCGA-FS-A1ZB	SKCM	TCGA	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation altering degron motif	0.76
p.D988N	TCGA-O2-A52S	LUSC	TCGA	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.25
p.D998E	DO223702	COAD	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.2778
p.R990L	DO219887	DLBC	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.3056
p.Q488K	DO229031	LICA	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1389
p.A1003E	DO229036	LICA	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.1389
p.Q994H	DO52182	LIHC	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation altering degron motif	0.7582
p.N989K	DO23907	LUAD	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.2778
p.G1000R	DO45540	LUSC	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.2222
p.G462E	DO220875	MELA	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.0556
p.R990H	DO222837	MELA	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.3056
p.C487R	DO46374	OV	ICGC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1667
p.R988Q	DO230637	PRAD	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.25
p.A984T	DO48665	SKCM	ICGC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.1389
p.Q488E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1389
p.Q488E	ACH-000766	Lung Cancer	CCLE	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1389
p.Q488E	NCI-H1648	lung	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1389
p.E996D	SIDM00472	Ovarian Carcinoma	GDSC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation altering degron motif	0.6758
p.E996D	ACH-001630	Ovarian Cancer	CCLE	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation altering degron motif	0.6758
p.E996D	PEO1	ovary	COSMIC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation altering degron motif	0.6758
p.H981R	SIDM00720	Mesothelioma	GDSC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.0556
p.H981R	NCI-H28	pleura	COSMIC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.0556
p.W473C	ACH-000868	Lung Cancer	CCLE	NWGGGYTDEP	CBL_PTK	472:481	Mutation altering degron motif	0.5889
p.T470N	ACH-001844	Bile Duct Cancer	CCLE	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.2778
p.M487V	IST-MES1	pleura	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1667
p.M487V	MOG-G-CCM	central nervous system	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1667
p.M487V	CL-34	large intestine	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1667
p.R491C	NUGC-3	stomach	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.0556
p.W487C	NB-4	haematopoietic and lymphoid tissue	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1667
p.A999V	SNU-1040	large intestine	COSMIC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.25
p.I489L	G-402	soft tissue	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.1111
p.H994R	NCI-H28	pleura	COSMIC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation altering degron motif	0.8244
p.P470A	BT-20	breast	COSMIC	NWGGGYTDEP	CBL_PTK	472:481	Mutation rewiring degron network	0.2778
p.G985R	LB996-RCC	kidney	COSMIC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation rewiring degron network	0.1667
p.A1001V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSETGE	DEG_Kelch_Keap1_1	991:996	Mutation substituting flanking lysine	0.3056

Kaplan plot for DGKI in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DGKI

UniProt ID: O75912

Entrez ID: 9162

Protein name: Diacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DGKI in