DegronMD

Uniprot ID: O75912

Source protein: Diacylglycerol kinase iota

Source gene: DGKI

Class: CBL_PTK

Location: 472:481

E3 ligase: CBL

DEGRON score: 0.8742

ASA_SCORE: 51.36

COIL: 0.9015

CONS_SCORE: 0.592

DSS_SCORE: 0.3184

HELIX: 0.0583

FCONS_SCORE: 0.8747

RIG_SCORE: 0.7603

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P481H	TCGA-22-5472	LUSC	TCGA	NWGGGYTDEP	CBL_PTK	0.7694
p.P481H	TCGA-D3-A3C8	SKCM	TCGA	NWGGGYTDEP	CBL_PTK	0.7694
p.P481H	DO27421	LUSC	ICGC	NWGGGYTDEP	CBL_PTK	0.7694
p.P481H	DO47636	SKCM	ICGC	NWGGGYTDEP	CBL_PTK	0.7694
p.E480K	TCGA-AP-A0LM	UCEC	TCGA	NWGGGYTDEP	CBL_PTK	0.591
p.E480K	DO43306	UCEC	ICGC	NWGGGYTDEP	CBL_PTK	0.591
p.W473C	ACH-000868	Lung Cancer	CCLE	NWGGGYTDEP	CBL_PTK	0.5889
p.T470N	ACH-001844	Bile Duct Cancer	CCLE	NWGGGYTDEP	CBL_PTK	0.2778
p.P470A	BT-20	breast	COSMIC	NWGGGYTDEP	CBL_PTK	0.2778
p.R469Q	TCGA-D3-A51T	SKCM	TCGA	NWGGGYTDEP	CBL_PTK	0.25
p.R469Q	DO47389	SKCM	ICGC	NWGGGYTDEP	CBL_PTK	0.25
p.L486R	TCGA-22-4605	LUSC	TCGA	NWGGGYTDEP	CBL_PTK	0.1944
p.L486R	DO27232	LUSC	ICGC	NWGGGYTDEP	CBL_PTK	0.1944
p.L467M	TCGA-DK-A3IL	BLCA	TCGA	NWGGGYTDEP	CBL_PTK	0.1944
p.L467M	DO555	BLCA	ICGC	NWGGGYTDEP	CBL_PTK	0.1944
p.C487R	DO46374	OV	ICGC	NWGGGYTDEP	CBL_PTK	0.1667
p.M487V	IST-MES1	pleura	COSMIC	NWGGGYTDEP	CBL_PTK	0.1667
p.M487V	MOG-G-CCM	central_nervous_system	COSMIC	NWGGGYTDEP	CBL_PTK	0.1667
p.M487V	CL-34	large_intestine	COSMIC	NWGGGYTDEP	CBL_PTK	0.1667
p.W487C	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	NWGGGYTDEP	CBL_PTK	0.1667
p.Q488K	DO229031	LICA	ICGC	NWGGGYTDEP	CBL_PTK	0.1389
p.Q488E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	NWGGGYTDEP	CBL_PTK	0.1389
p.Q488E	ACH-000766	Lung Cancer	CCLE	NWGGGYTDEP	CBL_PTK	0.1389
p.Q488E	NCI-H1648	lung	COSMIC	NWGGGYTDEP	CBL_PTK	0.1389
p.I489L	G-402	soft_tissue	COSMIC	NWGGGYTDEP	CBL_PTK	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons