DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NWGGGYTDEP
Uniprot ID:
Q13574
Source protein:
Diacylglycerol kinase zeta
Source gene:
DGKZ
Class:
CBL_PTK
Location:
391:400
E3 ligase:
CBL
DEGRON score:
0.9943
ASA_SCORE:
48.11
COIL:
0.9271
CONS_SCORE:
0.4135
DSS_SCORE:
0.3592
HELIX:
0.0325
FCONS_SCORE:
1.034
RIG_SCORE:
0.7351
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V407M
TCGA-27-2523
GBM
TCGA
NWGGGYTDEP
CBL_PTK
0.1389
p.S405N
TCGA-GN-A269
SKCM
TCGA
NWGGGYTDEP
CBL_PTK
0.1944
p.S405N
SIDM01618
B-Lymphoblastic Leukemia
GDSC
NWGGGYTDEP
CBL_PTK
0.1944
p.S405N
ACH-000942
Leukemia
CCLE
NWGGGYTDEP
CBL_PTK
0.1944
p.F386L
TCGA-R6-A6Y0
ESCA
TCGA
NWGGGYTDEP
CBL_PTK
0.1944
p.E402D
DO222566
BTCA
ICGC
NWGGGYTDEP
CBL_PTK
0.2778
p.E402K
DO10582
COAD
ICGC
NWGGGYTDEP
CBL_PTK
0.2778
p.L394M
DO232858
NACA
ICGC
NWGGGYTDEP
CBL_PTK
0.711
p.I391M
SIDM00266
Ewing's Sarcoma
GDSC
NWGGGYTDEP
CBL_PTK
0.7618
p.I391M
ACH-002103
Bone Cancer
CCLE
NWGGGYTDEP
CBL_PTK
0.7618
p.I391M
ES1
bone
COSMIC
NWGGGYTDEP
CBL_PTK
0.7618
Drug responses associated with DGKZ mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NWGGGYTDEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75912
Diacylglycerol kinase iota
CBL_PTK
472:481
NWGGGYTDEP
CBL
0.8742
More...
Q13574
Diacylglycerol kinase zeta
CBL_PTK
391:400
NWGGGYTDEP
CBL
0.9943
More...
