DegronMD

Uniprot ID: P78337

Source protein: Pituitary homeobox 1

Source gene: PITX1

Class: DEG_SCF_TRCP1_1

Location: 69:75

E3 ligase: BTRC

DEGRON score: 0.9915

ASA_SCORE: 69.0143

COIL: 0.9594

CONS_SCORE: 0.4363

DSS_SCORE: 0.7721

HELIX: 0.03

FCONS_SCORE: 1.0183

RIG_SCORE: 0.4891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S70N	TCGA-AJ-A8CW	UCEC	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	0.818
p.S70N	DO52400	UCEC	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	0.818
p.A80T	TCGA-AX-A2HC	UCEC	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	0.1944
p.A80T	DO41572	UCEC	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	0.1944
p.G71D	TCGA-D1-A2G0	UCEC	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	0.7198
p.G71D	DO43049	UCEC	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	0.7198
p.A72V	TCGA-DU-6392	LGG	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	0.5825
p.A72V	DO22237	LGG	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	0.5825
p.R60C	TCGA-XK-AAIW	PRAD	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	0.0833
p.R60C	DO51407	PRAD	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	0.0833
p.P83T	DO233732	GACA	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	0.1111
p.P67T	DO229018	LICA	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	0.2778
p.P67T	SIDM00417	Plasma Cell Myeloma	GDSC	DSGAGGT	DEG_SCF_TRCP1_1	0.2778
p.P67T	ACH-000626	Myeloma	CCLE	DSGAGGT	DEG_SCF_TRCP1_1	0.2778
p.P67T	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	DSGAGGT	DEG_SCF_TRCP1_1	0.2778
p.D82G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGAGGT	DEG_SCF_TRCP1_1	0.1389
p.D82G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGAGGT	DEG_SCF_TRCP1_1	0.1389
p.E63K	ACH-000916	Lung Cancer	CCLE	DSGAGGT	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78337	Pituitary homeobox 1	DEG_SCF_TRCP1_1	69:75	DSGAGGT	BTRC	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons