DegronMD - P78337(PITX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S70N	TCGA-AJ-A8CW	UCEC	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation altering degron motif	0.818
p.S70N	DO52400	UCEC	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation altering degron motif	0.818
p.A80T	TCGA-AX-A2HC	UCEC	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.1944
p.A80T	DO41572	UCEC	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.1944
p.A176T	TCGA-CK-6746	COAD	TCGA	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.25
p.A176T	DO7938	COAD	ICGC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.25
p.G71D	TCGA-D1-A2G0	UCEC	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation altering degron motif	0.7198
p.G71D	DO43049	UCEC	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation altering degron motif	0.7198
p.A72V	TCGA-DU-6392	LGG	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation altering degron motif	0.5825
p.A72V	DO22237	LGG	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation altering degron motif	0.5825
p.E172K	TCGA-EO-A22X	UCEC	TCGA	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation altering degron motif	0.591
p.E172K	DO43907	UCEC	ICGC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation altering degron motif	0.591
p.R60C	TCGA-XK-AAIW	PRAD	TCGA	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.0833
p.R60C	DO51407	PRAD	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.0833
p.S165G	DO233291	GACA	ICGC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.25
p.P83T	DO233732	GACA	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.1111
p.P162S	DO233855	GACA	ICGC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.1667
p.P162S	DO50970	LICA	ICGC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.1667
p.N182K	DO228974	LICA	ICGC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.0833
p.P67T	DO229018	LICA	ICGC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.2778
p.P67T	SIDM00417	Plasma Cell Myeloma	GDSC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.2778
p.P67T	ACH-000626	Myeloma	CCLE	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.2778
p.P67T	U-266	haematopoietic and lymphoid tissue	COSMIC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.2778
p.P170T	DO229041	LICA	ICGC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation altering degron motif	0.7031
p.D82G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.1389
p.D82G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.1389
p.A177S	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.2222
p.A177S	ACH-000860	Lung Cancer	CCLE	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.2222
p.A177S	NCI-H358	lung	COSMIC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.2222
p.G158R	SIDM01012	Other Blood Cancers	GDSC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.0556
p.G158R	ACH-000346	Leukemia	CCLE	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.0556
p.G158R	JVM-3	haematopoietic and lymphoid tissue	COSMIC	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.0556
p.E63K	ACH-000916	Lung Cancer	CCLE	DSGAGGT	DEG_SCF_TRCP1_1	69:75	Mutation rewiring degron network	0.1667
p.V174G	ACH-001558	Lung Cancer	CCLE	VQPYED	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.3056

Kaplan plot for PITX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PITX1

UniProt ID: P78337

Entrez ID: 5307

Protein name: Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PITX1 in