DegronMD

Uniprot ID: P78337

Source protein: Pituitary homeobox 1

Source gene: PITX1

Class: LIG_APCC_ABBA_1

Location: 168:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5169

ASA_SCORE: 39.9

COIL: 0.8647

CONS_SCORE: 0.6954

DSS_SCORE: 0.1093

HELIX: 0.0725

FCONS_SCORE: 1.0818

RIG_SCORE: 0.8479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A176T	TCGA-CK-6746	COAD	TCGA	VQPYED	LIG_APCC_ABBA_1	0.25
p.A176T	DO7938	COAD	ICGC	VQPYED	LIG_APCC_ABBA_1	0.25
p.E172K	TCGA-EO-A22X	UCEC	TCGA	VQPYED	LIG_APCC_ABBA_1	0.591
p.E172K	DO43907	UCEC	ICGC	VQPYED	LIG_APCC_ABBA_1	0.591
p.S165G	DO233291	GACA	ICGC	VQPYED	LIG_APCC_ABBA_1	0.25
p.P162S	DO233855	GACA	ICGC	VQPYED	LIG_APCC_ABBA_1	0.1667
p.P162S	DO50970	LICA	ICGC	VQPYED	LIG_APCC_ABBA_1	0.1667
p.N182K	DO228974	LICA	ICGC	VQPYED	LIG_APCC_ABBA_1	0.0833
p.P170T	DO229041	LICA	ICGC	VQPYED	LIG_APCC_ABBA_1	0.7031
p.A177S	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VQPYED	LIG_APCC_ABBA_1	0.2222
p.A177S	ACH-000860	Lung Cancer	CCLE	VQPYED	LIG_APCC_ABBA_1	0.2222
p.A177S	NCI-H358	lung	COSMIC	VQPYED	LIG_APCC_ABBA_1	0.2222
p.G158R	SIDM01012	Other Blood Cancers	GDSC	VQPYED	LIG_APCC_ABBA_1	0.0556
p.G158R	ACH-000346	Leukemia	CCLE	VQPYED	LIG_APCC_ABBA_1	0.0556
p.G158R	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	VQPYED	LIG_APCC_ABBA_1	0.0556
p.V174G	ACH-001558	Lung Cancer	CCLE	VQPYED	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78337	Pituitary homeobox 1	LIG_APCC_ABBA_1	168:173	VQPYED	APC,CDC20,FZR1	0.5169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons