DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_TRCP1_1

Location: 774:780

E3 ligase: BTRC

DEGRON score: 0.9975

ASA_SCORE: 77.5

COIL: 0.929

CONS_SCORE: 0.182

DSS_SCORE: 0.5841

HELIX: 0.0357

FCONS_SCORE: 0.7217

RIG_SCORE: 0.6268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S782G	TCGA-74-6577	GBM	TCGA	DSGASAT	DEG_SCF_TRCP1_1	0.2778
p.R787Q	TCGA-86-8073	LUAD	TCGA	DSGASAT	DEG_SCF_TRCP1_1	0.1389
p.R781W	TCGA-A5-A2K5	UCEC	TCGA	DSGASAT	DEG_SCF_TRCP1_1	0.3056
p.R781W	TCGA-BS-A0UV	UCEC	TCGA	DSGASAT	DEG_SCF_TRCP1_1	0.3056
p.R781W	TCGA-IB-A6UG	PAAD	TCGA	DSGASAT	DEG_SCF_TRCP1_1	0.3056
p.E771K	TCGA-DK-A1AC	BLCA	TCGA	DSGASAT	DEG_SCF_TRCP1_1	0.25
p.S780C	TCGA-DX-AB2E	SARC	TCGA	DSGASAT	DEG_SCF_TRCP1_1	0.7541
p.S782F	DO50814	LIRI	ICGC	DSGASAT	DEG_SCF_TRCP1_1	0.2778
p.S783Y	DO42745	UCEC	ICGC	DSGASAT	DEG_SCF_TRCP1_1	0.25
p.R787W	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	DSGASAT	DEG_SCF_TRCP1_1	0.1389
p.R787W	KYSE-410	oesophagus	COSMIC	DSGASAT	DEG_SCF_TRCP1_1	0.1389
p.A764V	SIDM00487	Colorectal Carcinoma	GDSC	DSGASAT	DEG_SCF_TRCP1_1	0.0556
p.A764V	CCK-81	large_intestine	COSMIC	DSGASAT	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_TRCP1_1	774:780	DSGASAT	BTRC	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons