DegronMD

Uniprot ID: Q5JWR5

Source protein: Protein dopey-1

Source gene: DOP1A

Class: DEG_SCF_TRCP1_1

Location: 1110:1116

E3 ligase: BTRC

DEGRON score: 0.9972

ASA_SCORE: 78.0286

COIL: 0.8323

CONS_SCORE: 0.2299

DSS_SCORE: 0.598

HELIX: 0.1131

FCONS_SCORE: 1.0719

RIG_SCORE: 0.6086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1118Y	SIDM01128	Small Cell Lung Carcinoma	GDSC	DSGCSQS	DEG_SCF_TRCP1_1	0.2778
p.D1118Y	NCI-H526	lung	COSMIC	DSGCSQS	DEG_SCF_TRCP1_1	0.2778
p.I1105M	HEC-1	endometrium	COSMIC	DSGCSQS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JWR5	Protein dopey-1	DEG_SCF_TRCP1_1	1110:1116	DSGCSQS	BTRC	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons