DegronMD

Uniprot ID: O14830

Source protein: Serine/threonine-protein phosphatase with EF-hands 2

Source gene: PPEF2

Class: DEG_SCF_TRCP1_1

Location: 744:749

E3 ligase: BTRC

DEGRON score: 0.7328

ASA_SCORE: 74.4667

COIL: 0.9663

CONS_SCORE: 0.3171

DSS_SCORE: 0.6181

HELIX: 0.0227

FCONS_SCORE: 1.0464

RIG_SCORE: 0.5797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A742V	TCGA-05-4415	LUAD	TCGA	DSGCSS	DEG_SCF_TRCP1_1	0.2778
p.A742V	DO25747	LUAD	ICGC	DSGCSS	DEG_SCF_TRCP1_1	0.2778
p.P737Q	TCGA-ER-A19B	SKCM	TCGA	DSGCSS	DEG_SCF_TRCP1_1	0.1389
p.P737Q	DO47491	SKCM	ICGC	DSGCSS	DEG_SCF_TRCP1_1	0.1389
p.G746D	DO233867	GACA	ICGC	DSGCSS	DEG_SCF_TRCP1_1	0.7198
p.P737T	DO229027	LICA	ICGC	DSGCSS	DEG_SCF_TRCP1_1	0.1389
p.G751A	DO46611	OV	ICGC	DSGCSS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14830	Serine/threonine-protein phosphatase with EF-hands 2	DEG_SCF_TRCP1_1	744:749	DSGCSS	BTRC	0.7328	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons