DegronMD

Uniprot ID: Q9NSI8

Source protein: SAM domain-containing protein SAMSN-1

Source gene: SAMSN1

Class: DEG_SCF_TRCP1_1

Location: 337:343

E3 ligase: BTRC

DEGRON score: 0.9648

ASA_SCORE: 28.3286

COIL: 0.6873

CONS_SCORE: 0.9121

DSS_SCORE: 0.5331

HELIX: 0.0974

FCONS_SCORE: 1.2968

RIG_SCORE: 0.6882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D340Y	TCGA-95-7567	LUAD	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	0.7325
p.D340N	TCGA-AX-A2HC	UCEC	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	0.6932
p.I344M	TCGA-C4-A0EZ	BLCA	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	0.3056
p.N333S	TCGA-CN-4727	HNSC	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	0.2222
p.E336K	TCGA-D3-A8GI	SKCM	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	0.3056
p.D343Y	TCGA-DK-A6AW	BLCA	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	0.7325
p.I350T	TCGA-EW-A2FW	BRCA	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	0.1389
p.E346D	SIDM00652	Small Cell Lung Carcinoma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	0.25
p.E346D	NCI-H1105	lung	COSMIC	DSGCYIS	DEG_SCF_TRCP1_1	0.25
p.H348N	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	0.1944
p.H348N	NCI-H1563	lung	COSMIC	DSGCYIS	DEG_SCF_TRCP1_1	0.1944
p.L330H	SIDM01574	Plasma Cell Myeloma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	0.1389
p.I344V	SIDM01442	Glioma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	0.3056
p.D333N	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGCYIS	DEG_SCF_TRCP1_1	0.2222
p.N328Y	IHH-4	thyroid	COSMIC	DSGCYIS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSI8	SAM domain-containing protein SAMSN-1	DEG_SCF_TRCP1_1	337:343	DSGCYIS	BTRC	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons