DegronMD - Q9NSI8(SAMSN1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T183R	TCGA-12-0670	GBM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.5
p.T183R	DO12226	GBM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.5
p.E160K	TCGA-3N-A9WC	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.5833
p.E160K	DO51234	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.5833
p.D340Y	TCGA-95-7567	LUAD	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation altering degron motif	0.7325
p.D340N	TCGA-AX-A2HC	UCEC	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation altering degron motif	0.6932
p.D165Y	TCGA-AX-A2HC	UCEC	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2778
p.D165Y	DO41572	UCEC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2778
p.I344M	TCGA-C4-A0EZ	BLCA	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.3056
p.N333S	TCGA-CN-4727	HNSC	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.2222
p.E336K	TCGA-D3-A8GI	SKCM	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.3056
p.D162N	TCGA-D9-A6EC	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1944
p.D162N	TCGA-FR-A3YO	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1944
p.D162N	DO37419	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1944
p.D162N	DO50291	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1944
p.G166E	TCGA-DA-A1HW	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.3056
p.G166E	DO38129	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.3056
p.D343Y	TCGA-DK-A6AW	BLCA	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation altering degron motif	0.7325
p.E159G	TCGA-EI-6508	READ	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1111
p.E159G	DO36389	READ	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1111
p.D162V	TCGA-EJ-5526	PRAD	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1944
p.D162V	DO36252	PRAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1944
p.I350T	TCGA-EW-A2FW	BRCA	TCGA	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.1389
p.D165H	TCGA-JW-A5VL	CESC	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2778
p.D165H	DO49976	CESC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2778
p.N178H	DO222884	COCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1944
p.E167A	DO234350	ESAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.7701
p.R173I	DO48268	ESCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.8102
p.N168S	DO220886	MELA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.7069
p.A169V	DO220901	MELA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.6936
p.L157F	DO48945	PBCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.0556
p.C166S	DO220312	SARC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.3056
p.G177E	DO37659	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.6667
p.D169N	DO37444	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.6932
p.L158V	DO47823	STAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.0833
p.S161P	DO219773	UCEC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.1667
p.G177V	DO49073	UCEC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.6667
p.I179T	SIDM00625	Other Sarcomas	GDSC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.6111
p.I179T	MES-SA	soft tissue	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation blocking phosphorylation signal	0.6111
p.E163Q	SIDM00938	Breast Carcinoma	GDSC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2222
p.E163Q	CAL-148	breast	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2222
p.E346D	SIDM00652	Small Cell Lung Carcinoma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.25
p.E346D	NCI-H1105	lung	COSMIC	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.25
p.H348N	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.1944
p.H348N	NCI-H1563	lung	COSMIC	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.1944
p.L330H	SIDM01574	Plasma Cell Myeloma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.1389
p.I344V	SIDM01442	Glioma	GDSC	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.3056
p.R167H	ACH-000270	Pancreatic Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.8244
p.R167H	ACH-001098	Pancreatic Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.8244
p.R167H	HPAC	pancreas	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.8244
p.D333N	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation rewiring degron network	0.2222
p.T175M	ACH-001369	Ovarian Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2778
p.P163L	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.2222
p.N170S	MFE-319	endometrium	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.7069
p.L157H	D-542MG	central nervous system	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation rewiring degron network	0.0556
p.N328Y	IHH-4	thyroid	COSMIC	DSGCYIS	DEG_SCF_TRCP1_1	337:343	Mutation substituting flanking lysine	0.1944
p.R167Q	CML-T1	haematopoietic and lymphoid tissue	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	167:173	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAMSN1

UniProt ID: Q9NSI8

Entrez ID: 64092

Protein name: SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SAMSN1 in