DegronMD

Uniprot ID: Q9NSI8

Source protein: SAM domain-containing protein SAMSN-1

Source gene: SAMSN1

Class: LIG_APCC_ABBAyCdc20_2

Location: 167:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6304

ASA_SCORE: 25.6429

COIL: 0.1461

CONS_SCORE: 0.7964

DSS_SCORE: 0.3962

HELIX: 0.0127

FCONS_SCORE: 1.0412

RIG_SCORE: 0.746

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T183R	TCGA-12-0670	GBM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.5
p.T183R	DO12226	GBM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.5
p.E160K	TCGA-3N-A9WC	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.5833
p.E160K	DO51234	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.5833
p.D165Y	TCGA-AX-A2HC	UCEC	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D165Y	DO41572	UCEC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D162N	TCGA-D9-A6EC	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D162N	TCGA-FR-A3YO	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D162N	DO37419	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D162N	DO50291	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G166E	TCGA-DA-A1HW	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G166E	DO38129	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E159G	TCGA-EI-6508	READ	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E159G	DO36389	READ	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D162V	TCGA-EJ-5526	PRAD	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D162V	DO36252	PRAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D165H	TCGA-JW-A5VL	CESC	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D165H	DO49976	CESC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.N178H	DO222884	COCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E167A	DO234350	ESAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.7701
p.R173I	DO48268	ESCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8102
p.N168S	DO220886	MELA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.7069
p.A169V	DO220901	MELA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6936
p.L157F	DO48945	PBCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.C166S	DO220312	SARC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G177E	DO37659	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6667
p.D169N	DO37444	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6932
p.L158V	DO47823	STAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S161P	DO219773	UCEC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G177V	DO49073	UCEC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6667
p.I179T	SIDM00625	Other Sarcomas	GDSC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6111
p.I179T	MES-SA	soft_tissue	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6111
p.E163Q	SIDM00938	Breast Carcinoma	GDSC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E163Q	CAL-148	breast	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R167H	ACH-000270	Pancreatic Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R167H	ACH-001098	Pancreatic Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R167H	HPAC	pancreas	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.T175M	ACH-001369	Ovarian Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P163L	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.N170S	MFE-319	endometrium	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.7069
p.L157H	D-542MG	central_nervous_system	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R167Q	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	LIG_APCC_ABBAyCdc20_2	558:564	RARVHTD	APC,CDC20,FZR1	0.5427	More...
Q9NSI8	SAM domain-containing protein SAMSN-1	LIG_APCC_ABBAyCdc20_2	167:173	RARVHTD	APC,CDC20,FZR1	0.6304	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RARVHTD

Degron related mutations and impact score

Drug responses associated with SAMSN1 mutations

All proteins holding degron of RARVHTD