DegronMD

Uniprot ID: O94885

Source protein: SAM and SH3 domain-containing protein 1

Source gene: SASH1

Class: LIG_APCC_ABBAyCdc20_2

Location: 558:564

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5427

ASA_SCORE: 32.9

COIL: 0.2451

CONS_SCORE: 0.5862

DSS_SCORE: 0.5198

HELIX: 0.0156

FCONS_SCORE: 1.1537

RIG_SCORE: 0.7219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G557R	TCGA-06-0168	GBM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G557R	TCGA-AA-3821	COAD	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G557R	DO9314	COAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R558H	TCGA-AP-A1DH	UCEC	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R558H	TCGA-F4-6856	COAD	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R558H	DO9114	COAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R558H	DO43995	UCEC	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8244
p.P569S	TCGA-BF-A5EQ	SKCM	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P569S	DO219452	SKCM	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P569S	DO229542	UTCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P550S	TCGA-CM-6674	COAD	TCGA	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P550S	DO10092	COAD	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R558C	DO222576	COCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8301
p.P554L	DO228011	SKCA	ICGC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P554L	SIDM01617	Endometrial Carcinoma	GDSC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P554L	ACH-000994	Endometrial/Uterine Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D564N	SIDM00603	Head and Neck Carcinoma	GDSC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D564N	ACH-001543	Head and Neck Cancer	CCLE	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D564N	KOSC-2	upper_aerodigestive_tract	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.6932
p.R564W	HT-115	large_intestine	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R564W	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	RARVHTD	LIG_APCC_ABBAyCdc20_2	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	LIG_APCC_ABBAyCdc20_2	558:564	RARVHTD	APC,CDC20,FZR1	0.5427	More...
Q9NSI8	SAM domain-containing protein SAMSN-1	LIG_APCC_ABBAyCdc20_2	167:173	RARVHTD	APC,CDC20,FZR1	0.6304	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons