DegronMD

Uniprot ID: Q6P3X8

Source protein: PiggyBac transposable element-derived protein 2

Source gene: PGBD2

Class: DEG_SCF_TRCP1_1

Location: 58:64

E3 ligase: BTRC

DEGRON score: 0.9011

ASA_SCORE: 78.5429

COIL: 0.8561

CONS_SCORE: 0.4429

DSS_SCORE: 0.7586

HELIX: 0.1033

FCONS_SCORE: 0.9922

RIG_SCORE: 0.6322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S59L	TCGA-33-4533	LUSC	TCGA	DSGDEDS	DEG_SCF_TRCP1_1	0.7667
p.D48N	TCGA-AX-A3G8	UCEC	TCGA	DSGDEDS	DEG_SCF_TRCP1_1	0.0556
p.D48N	TCGA-B5-A0JY	UCEC	TCGA	DSGDEDS	DEG_SCF_TRCP1_1	0.0556
p.L65V	DO14902	HNSC	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	0.3056
p.L65V	KYSE-70	oesophagus	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	0.3056
p.L65V	HuO9	bone	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	0.3056
p.L65V	KU-19-19	urinary_tract	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	0.3056
p.L65V	SNU-81	large_intestine	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	0.3056
p.R63Q	DO225415	LAML	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	0.7329
p.R63Q	DO225430	LAML	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	0.7329
p.R63Q	DO51017	LAML	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	0.7329
p.D70Y	DO228948	LICA	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	0.1667
p.S61I	DO229051	LICA	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	0.7341
p.S56L	DO27572	LUSC	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	0.2778
p.A51V	SIDM00889	Cervical Carcinoma	GDSC	DSGDEDS	DEG_SCF_TRCP1_1	0.1389
p.A51V	ACH-001333	Cervical Cancer	CCLE	DSGDEDS	DEG_SCF_TRCP1_1	0.1389
p.A51V	C-33-A	cervix	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3X8	PiggyBac transposable element-derived protein 2	DEG_SCF_TRCP1_1	58:64	DSGDEDS	BTRC	0.9011	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons