DegronMD - Q6P3X8(PGBD2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R587S	TCGA-27-2523	GBM	TCGA	HIR	DEG_APCC_TPR_1	590:592	Mutation rewiring degron network	0.25
p.S59L	TCGA-33-4533	LUSC	TCGA	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7667
p.E588D	TCGA-34-5234	LUSC	TCGA	HIR	DEG_APCC_TPR_1	590:592	Mutation rewiring degron network	0.2778
p.G143C	TCGA-AA-3949	COAD	TCGA	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.G143C	SIDM00333	Endometrial Carcinoma	GDSC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.G143C	ACH-000988	Endometrial/Uterine Cancer	CCLE	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.G143C	MFE-319	endometrium	COSMIC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.D48N	TCGA-AX-A3G8	UCEC	TCGA	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.0556
p.D48N	TCGA-B5-A0JY	UCEC	TCGA	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.0556
p.R592Q	TCGA-D5-6540	COAD	TCGA	HIR	DEG_APCC_TPR_1	590:592	Mutation altering degron motif	0.7329
p.C585Y	TCGA-D8-A1JA	BRCA	TCGA	HIR	DEG_APCC_TPR_1	590:592	Mutation rewiring degron network	0.1944
p.V142L	TCGA-EL-A3MY	THCA	TCGA	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.A583S	TCGA-FD-A5C0	BLCA	TCGA	HIR	DEG_APCC_TPR_1	590:592	Mutation rewiring degron network	0.1389
p.V159M	DO224755	BRCA	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.G140C	DO7798	COAD	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.R160H	DO234463	ESAD	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.L65V	DO14902	HNSC	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.3056
p.L65V	KYSE-70	oesophagus	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.3056
p.L65V	HuO9	bone	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.3056
p.L65V	KU-19-19	urinary tract	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.3056
p.L65V	SNU-81	large intestine	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.3056
p.R144S	DO15422	HNSC	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.3056
p.R63Q	DO225415	LAML	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7329
p.R63Q	DO225430	LAML	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7329
p.R63Q	DO51017	LAML	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7329
p.D70Y	DO228948	LICA	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.1667
p.I158T	DO228988	LICA	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1111
p.S61I	DO229051	LICA	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation altering degron motif	0.7341
p.E155V	DO218923	LUAD	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.S56L	DO27572	LUSC	ICGC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.2778
p.R160C	DO222749	MELA	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.G145A	DO29358	OV	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.754
p.N152D	DO36556	READ	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.M142I	DO228012	SKCA	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.V139L	DO39610	THCA	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1667
p.D135Y	DO219773	UCEC	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation substituting flanking lysine	0.1667
p.K140N	DO41211	UCEC	ICGC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.I157M	SIDM00586	Hepatocellular Carcinoma	GDSC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1389
p.I157M	ACH-000475	Liver Cancer	CCLE	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1389
p.I157M	huH-1	liver	COSMIC	FELFFD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1389
p.A51V	SIDM00889	Cervical Carcinoma	GDSC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.1389
p.A51V	ACH-001333	Cervical Cancer	CCLE	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.1389
p.A51V	C-33-A	cervix	COSMIC	DSGDEDS	DEG_SCF_TRCP1_1	58:64	Mutation rewiring degron network	0.1389
p.R587G	SIDM00487	Colorectal Carcinoma	GDSC	HIR	DEG_APCC_TPR_1	590:592	Mutation rewiring degron network	0.25
p.R587G	ACH-000963	Colon/Colorectal Cancer	CCLE	HIR	DEG_APCC_TPR_1	590:592	Mutation rewiring degron network	0.25
p.R587G	CCK-81	large intestine	COSMIC	HIR	DEG_APCC_TPR_1	590:592	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PGBD2

UniProt ID: Q6P3X8

Entrez ID: 267002

Protein name: PiggyBac transposable element-derived protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PGBD2 in