DegronMD

Uniprot ID: Q6P3X8

Source protein: PiggyBac transposable element-derived protein 2

Source gene: PGBD2

Class: LIG_APCC_ABBA_1

Location: 145:150

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6074

ASA_SCORE: 36.3167

COIL: 0.363

CONS_SCORE: 0.7673

DSS_SCORE: 0.0855

HELIX: 0.6308

FCONS_SCORE: 1.2875

RIG_SCORE: 0.9164

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G145A	DO29358	OV	ICGC	FELFFD	LIG_APCC_ABBA_1	0.754
p.R144S	DO15422	HNSC	ICGC	FELFFD	LIG_APCC_ABBA_1	0.3056
p.G143C	TCGA-AA-3949	COAD	TCGA	FELFFD	LIG_APCC_ABBA_1	0.2778
p.G143C	SIDM00333	Endometrial Carcinoma	GDSC	FELFFD	LIG_APCC_ABBA_1	0.2778
p.G143C	ACH-000988	Endometrial/Uterine Cancer	CCLE	FELFFD	LIG_APCC_ABBA_1	0.2778
p.G143C	MFE-319	endometrium	COSMIC	FELFFD	LIG_APCC_ABBA_1	0.2778
p.N152D	DO36556	READ	ICGC	FELFFD	LIG_APCC_ABBA_1	0.2778
p.V142L	TCGA-EL-A3MY	THCA	TCGA	FELFFD	LIG_APCC_ABBA_1	0.25
p.M142I	DO228012	SKCA	ICGC	FELFFD	LIG_APCC_ABBA_1	0.25
p.G140C	DO7798	COAD	ICGC	FELFFD	LIG_APCC_ABBA_1	0.1944
p.E155V	DO218923	LUAD	ICGC	FELFFD	LIG_APCC_ABBA_1	0.1944
p.K140N	DO41211	UCEC	ICGC	FELFFD	LIG_APCC_ABBA_1	0.1944
p.V139L	DO39610	THCA	ICGC	FELFFD	LIG_APCC_ABBA_1	0.1667
p.D135Y	DO219773	UCEC	ICGC	FELFFD	LIG_APCC_ABBA_1	0.1667
p.I157M	SIDM00586	Hepatocellular Carcinoma	GDSC	FELFFD	LIG_APCC_ABBA_1	0.1389
p.I157M	ACH-000475	Liver Cancer	CCLE	FELFFD	LIG_APCC_ABBA_1	0.1389
p.I157M	huH-1	liver	COSMIC	FELFFD	LIG_APCC_ABBA_1	0.1389
p.I158T	DO228988	LICA	ICGC	FELFFD	LIG_APCC_ABBA_1	0.1111
p.V159M	DO224755	BRCA	ICGC	FELFFD	LIG_APCC_ABBA_1	0.0833
p.R160H	DO234463	ESAD	ICGC	FELFFD	LIG_APCC_ABBA_1	0.0556
p.R160C	DO222749	MELA	ICGC	FELFFD	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3X8	PiggyBac transposable element-derived protein 2	LIG_APCC_ABBA_1	145:150	FELFFD	APC,CDC20,FZR1	0.6074	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons