DegronMD

Uniprot ID: Q6P3X8

Source protein: PiggyBac transposable element-derived protein 2

Source gene: PGBD2

Class: DEG_APCC_TPR_1

Location: 590:592

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7275

ASA_SCORE: 100.8

COIL: 0.7253

CONS_SCORE: 0.424

DSS_SCORE: 0.5912

HELIX: 0.2733

FCONS_SCORE: 0.9467

RIG_SCORE: 0.8506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R587S	TCGA-27-2523	GBM	TCGA	HIR	DEG_APCC_TPR_1	0.25
p.E588D	TCGA-34-5234	LUSC	TCGA	HIR	DEG_APCC_TPR_1	0.2778
p.R592Q	TCGA-D5-6540	COAD	TCGA	HIR	DEG_APCC_TPR_1	0.7329
p.C585Y	TCGA-D8-A1JA	BRCA	TCGA	HIR	DEG_APCC_TPR_1	0.1944
p.A583S	TCGA-FD-A5C0	BLCA	TCGA	HIR	DEG_APCC_TPR_1	0.1389
p.R587G	SIDM00487	Colorectal Carcinoma	GDSC	HIR	DEG_APCC_TPR_1	0.25
p.R587G	ACH-000963	Colon/Colorectal Cancer	CCLE	HIR	DEG_APCC_TPR_1	0.25
p.R587G	CCK-81	large_intestine	COSMIC	HIR	DEG_APCC_TPR_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DY1	Zinc finger protein 626	DEG_APCC_TPR_1	526:528	HIR	APC,CDC20,FZR1	0.9616	More...
Q6P3X8	PiggyBac transposable element-derived protein 2	DEG_APCC_TPR_1	590:592	HIR	APC,CDC20,FZR1	0.7275	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons