DegronMD

Uniprot ID: Q68DY1

Source protein: Zinc finger protein 626

Source gene: ZNF626

Class: DEG_APCC_TPR_1

Location: 526:528

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9616

ASA_SCORE: 140.0667

COIL: 0.9643

CONS_SCORE: 0.5175

DSS_SCORE: 0.9249

HELIX: 0.005

FCONS_SCORE: 1.0795

RIG_SCORE: 0.7973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L525R	TCGA-29-2429	OV	TCGA	HIR	DEG_APCC_TPR_1	0.3056
p.L525R	DO30580	OV	ICGC	HIR	DEG_APCC_TPR_1	0.3056
p.H526R	DO222874	COCA	ICGC	HIR	DEG_APCC_TPR_1	0.7133
p.R528G	SIDM00007	Other Solid Cancers	GDSC	HIR	DEG_APCC_TPR_1	0.7568
p.R528G	ACH-001550	Skin Cancer	CCLE	HIR	DEG_APCC_TPR_1	0.7568
p.R528G	MCC13	skin	COSMIC	HIR	DEG_APCC_TPR_1	0.7568
p.L524S	SIDM00254	Neuroblastoma	GDSC	HIR	DEG_APCC_TPR_1	0.2778
p.H522D	SIDM01757	Bladder Carcinoma	GDSC	HIR	DEG_APCC_TPR_1	0.2222
p.H522D	ACH-000741	Bladder Cancer	CCLE	HIR	DEG_APCC_TPR_1	0.2222
p.H520Q	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	HIR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DY1	Zinc finger protein 626	DEG_APCC_TPR_1	526:528	HIR	APC,CDC20,FZR1	0.9616	More...
Q6P3X8	PiggyBac transposable element-derived protein 2	DEG_APCC_TPR_1	590:592	HIR	APC,CDC20,FZR1	0.7275	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons