DegronMD

Uniprot ID: O60333

Source protein: Kinesin-like protein KIF1B

Source gene: KIF1B

Class: DEG_SCF_TRCP1_1

Location: 1567:1573

E3 ligase: BTRC

DEGRON score: 0.8928

ASA_SCORE: 72.6286

COIL: 0.7559

CONS_SCORE: 0.3142

DSS_SCORE: 0.4935

HELIX: 0.213

FCONS_SCORE: 0.983

RIG_SCORE: 0.7123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1572Y	TCGA-38-4631	LUAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	0.7325
p.I1569V	TCGA-E6-A1LX	UCEC	TCGA	DSGDIES	DEG_SCF_TRCP1_1	0.7076
p.S1564F	TCGA-HE-7130	KIRP	TCGA	DSGDIES	DEG_SCF_TRCP1_1	0.25
p.R1571W	TCGA-HF-A5NB	STAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	0.8634
p.R1571W	TCGA-RD-A8NB	STAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	0.8634
p.R1571W	TCGA-WS-AB45	COAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	0.8634
p.R1571W	SIDM00216	Colorectal Carcinoma	GDSC	DSGDIES	DEG_SCF_TRCP1_1	0.8634
p.R1571W	SNU-175	large_intestine	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	0.8634
p.V1575M	ACH-000221	Liver Cancer	CCLE	DSGDIES	DEG_SCF_TRCP1_1	0.2778
p.V1575M	SNU-398	liver	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	0.2778
p.A1557T	ACH-001578	Embryonal Cancer	CCLE	DSGDIES	DEG_SCF_TRCP1_1	0.0556
p.A1557T	NCCIT	testis	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	0.0556
p.E1578K	ACH-002024	Colon/Colorectal Cancer	CCLE	DSGDIES	DEG_SCF_TRCP1_1	0.1944
p.G1576D	SNU-1040	large_intestine	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	0.25
p.C1581Y	NB13	autonomic_ganglia	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	0.1111
p.V1578I	LU-165	lung	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	DEG_SCF_TRCP1_1	1567:1573	DSGDIES	BTRC	0.8928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons