DegronMD - O60333(KIF1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E797D	TCGA-06-5416	GBM	TCGA	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.6758
p.D1572Y	TCGA-38-4631	LUAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation altering degron motif	0.7325
p.N312H	TCGA-AX-A1CE	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.N312H	DO42280	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2222
p.V1558I	TCGA-CM-4743	COAD	TCGA	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7076
p.V1558I	SIDM00845	Burkitt's Lymphoma	GDSC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7076
p.V1558I	SIDM00292	Small Cell Lung Carcinoma	GDSC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7076
p.V1558I	SIDM01519	Head and Neck Carcinoma	GDSC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7076
p.V1558I	LU-165	lung	COSMIC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7076
p.R807Q	TCGA-CV-7095	HNSC	TCGA	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.2222
p.R318L	TCGA-D3-A2JC	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0556
p.R318L	TCGA-ER-A19F	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0556
p.R318L	DO37679	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0556
p.R318L	DO47578	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0556
p.E1639K	TCGA-DK-A6AW	BLCA	TCGA	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation rewiring degron network	0.1944
p.D302N	TCGA-DU-6407	LGG	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.3056
p.D302N	DO22295	LGG	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.3056
p.I1569V	TCGA-E6-A1LX	UCEC	TCGA	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation altering degron motif	0.7076
p.P1625S	TCGA-EB-A3XF	SKCM	TCGA	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation rewiring degron network	0.2222
p.P299S	TCGA-EB-A41A	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.3333
p.P299S	TCGA-EE-A2MM	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.3333
p.P299S	DO222678	MELA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.3333
p.P299S	DO229453	SKCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.3333
p.P299S	DO37770	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.3333
p.P299S	DO37429	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.3333
p.D296Y	TCGA-EO-A22R	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.25
p.D296Y	DO42713	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.25
p.S1564F	TCGA-HE-7130	KIRP	TCGA	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation rewiring degron network	0.3056
p.S1564F	TCGA-HE-7130	KIRP	TCGA	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.25
p.R1571W	TCGA-HF-A5NB	STAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation altering degron motif	0.8634
p.R1571W	TCGA-RD-A8NB	STAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation altering degron motif	0.8634
p.R1571W	TCGA-WS-AB45	COAD	TCGA	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation altering degron motif	0.8634
p.R1571W	SIDM00216	Colorectal Carcinoma	GDSC	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation altering degron motif	0.8634
p.R1571W	SNU-175	large intestine	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation altering degron motif	0.8634
p.D811H	TCGA-UC-A7PF	CESC	TCGA	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.1111
p.D296H	TCGA-ZF-AA4V	BLCA	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.25
p.D296H	DO219087	BLCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.25
p.E801K	DO554	BLCA	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.7022
p.E311G	DO223046	ESCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.25
p.A808V	DO14894	HNSC	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.1944
p.L802F	DO228985	LICA	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.587
p.L802F	DO229037	LICA	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.587
p.K786N	DO229045	LICA	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation substituting flanking lysine	0.1667
p.G810W	DO229009	LICA	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.1389
p.K786Q	DO22866	LIHC	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation substituting flanking lysine	0.1667
p.D800N	DO24656	LUAD	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.6932
p.S1641C	DO26536	LUSC	ICGC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation blocking phosphorylation signal	0.5833
p.P808L	DO220854	MELA	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.1944
p.E311K	DO220880	MELA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.25
p.E311K	SIDM00861	Ovarian Carcinoma	GDSC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.25
p.E311K	ES-2	ovary	COSMIC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.25
p.P1631T	DO222678	MELA	ICGC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation altering degron motif	0.7031
p.P1631T	DO37770	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation altering degron motif	0.7031
p.P1619L	DO222837	MELA	ICGC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation rewiring degron network	0.0556
p.V796I	DO33091	PACA	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.7076
p.P804S	DO220223	SARC	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.3056
p.P804S	DO37831	SKCM	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.3056
p.T797A	DO37631	SKCM	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.6028
p.P1636L	DO37881	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation rewiring degron network	0.2778
p.G797C	DO38177	SKCM	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.76
p.V806I	DO47745	STAD	ICGC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.25
p.R310Q	SIDM00933	Breast Carcinoma	GDSC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2778
p.R310Q	CAL-51	breast	COSMIC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.2778
p.E1628K	SIDM00845	Burkitt's Lymphoma	GDSC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation rewiring degron network	0.3056
p.Y793C	SIDM01109	Other Sarcomas	GDSC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.25
p.Y793C	SK-LMS-1	soft tissue	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.25
p.E1639G	SIDM00282	Colorectal Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation rewiring degron network	0.1944
p.E1639G	CW-2	large intestine	COSMIC	LTPSST	DEG_SCF_FBW7_1	1629:1634	Mutation rewiring degron network	0.1944
p.G1556D	SIDM00217	Colorectal Carcinoma	GDSC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation rewiring degron network	0.2778
p.G1556D	SNU-1040	large intestine	COSMIC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation rewiring degron network	0.2778
p.S795Y	SIDM00534	Colorectal Carcinoma	GDSC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.3056
p.S795Y	HT-115	large intestine	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.3056
p.C1561Y	SIDM00257	Neuroblastoma	GDSC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7087
p.C1561Y	NB13	autonomic ganglia	COSMIC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7087
p.L313F	SIDM01519	Head and Neck Carcinoma	GDSC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1944
p.V1575M	ACH-000221	Liver Cancer	CCLE	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.2778
p.V1575M	SNU-398	liver	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.2778
p.R316Q	ACH-000856	Breast Cancer	CCLE	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R316Q	CAL-51	breast	COSMIC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.E317K	ACH-000906	Ovarian Cancer	CCLE	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0833
p.E317K	ES-2	ovary	COSMIC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0833
p.T795I	ACH-000931	Skin Cancer	CCLE	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.3056
p.T795I	ACH-001024	Skin Cancer	CCLE	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.3056
p.T795I	CHL-1	skin	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.3056
p.K297N	ACH-000986	Colon/Colorectal Cancer	CCLE	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.2778
p.K297N	HT-115	large intestine	COSMIC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.2778
p.A1557T	ACH-001578	Embryonal Cancer	CCLE	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation rewiring degron network	0.3056
p.A1557T	ACH-001578	Embryonal Cancer	CCLE	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.0556
p.A1557T	NCCIT	testis	COSMIC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation rewiring degron network	0.3056
p.A1557T	NCCIT	testis	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.0556
p.E1578K	ACH-002024	Colon/Colorectal Cancer	CCLE	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.1944
p.S295I	SNU-1040	large intestine	COSMIC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.G1576D	SNU-1040	large intestine	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.25
p.V1561M	SNU-398	liver	COSMIC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation altering degron motif	0.7208
p.V1549M	SNU-398	liver	COSMIC	ITPSES	DEG_SCF_FBW7_1	1558:1563	Mutation rewiring degron network	0.0833
p.E790D	HCE-4	oesophagus	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.1667
p.C1581Y	NB13	autonomic ganglia	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.1111
p.Y813C	SK-LMS-1	soft tissue	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation substituting flanking lysine	0.1667
p.V1578I	LU-165	lung	COSMIC	DSGDIES	DEG_SCF_TRCP1_1	1567:1573	Mutation rewiring degron network	0.1944
p.D803E	LC-1-sq	lung	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.6758
p.D791E	LC-1-sq	lung	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation rewiring degron network	0.1944
p.E802D	HCE-4	oesophagus	COSMIC	DTLYSPLP	CBL_PTK	796:803	Mutation altering degron motif	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF1B

UniProt ID: O60333

Entrez ID: 23095

Protein name: Kinesin-like protein KIF1B (Klp)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF1B in