DegronMD

Uniprot ID: O60333

Source protein: Kinesin-like protein KIF1B

Source gene: KIF1B

Class: DEG_SCF_FBW7_1

Location: 1558:1563

E3 ligase: FBXW7

DEGRON score: 0.9866

ASA_SCORE: 75.9667

COIL: 0.912

CONS_SCORE: 0.2753

DSS_SCORE: 0.5124

HELIX: 0.0482

FCONS_SCORE: 0.8924

RIG_SCORE: 0.6701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1558I	TCGA-CM-4743	COAD	TCGA	ITPSES	DEG_SCF_FBW7_1	0.7076
p.V1558I	SIDM00845	Burkitt's Lymphoma	GDSC	ITPSES	DEG_SCF_FBW7_1	0.7076
p.V1558I	SIDM00292	Small Cell Lung Carcinoma	GDSC	ITPSES	DEG_SCF_FBW7_1	0.7076
p.V1558I	SIDM01519	Head and Neck Carcinoma	GDSC	ITPSES	DEG_SCF_FBW7_1	0.7076
p.V1558I	LU-165	lung	COSMIC	ITPSES	DEG_SCF_FBW7_1	0.7076
p.S1564F	TCGA-HE-7130	KIRP	TCGA	ITPSES	DEG_SCF_FBW7_1	0.3056
p.G1556D	SIDM00217	Colorectal Carcinoma	GDSC	ITPSES	DEG_SCF_FBW7_1	0.2778
p.G1556D	SNU-1040	large_intestine	COSMIC	ITPSES	DEG_SCF_FBW7_1	0.2778
p.C1561Y	SIDM00257	Neuroblastoma	GDSC	ITPSES	DEG_SCF_FBW7_1	0.7087
p.C1561Y	NB13	autonomic_ganglia	COSMIC	ITPSES	DEG_SCF_FBW7_1	0.7087
p.A1557T	ACH-001578	Embryonal Cancer	CCLE	ITPSES	DEG_SCF_FBW7_1	0.3056
p.A1557T	NCCIT	testis	COSMIC	ITPSES	DEG_SCF_FBW7_1	0.3056
p.V1561M	SNU-398	liver	COSMIC	ITPSES	DEG_SCF_FBW7_1	0.7208
p.V1549M	SNU-398	liver	COSMIC	ITPSES	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	DEG_SCF_FBW7_1	1558:1563	ITPSES	FBXW7	0.9866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons