DegronMD

Uniprot ID: O60333

Source protein: Kinesin-like protein KIF1B

Source gene: KIF1B

Class: LIG_APCC_ABBA_1

Location: 303:308

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.979

ASA_SCORE: 68.1167

COIL: 0.7672

CONS_SCORE: 0.7105

DSS_SCORE: 0.1808

HELIX: 0.1507

FCONS_SCORE: 1.2613

RIG_SCORE: 0.8757

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N312H	TCGA-AX-A1CE	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.2222
p.N312H	DO42280	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.2222
p.R318L	TCGA-D3-A2JC	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.0556
p.R318L	TCGA-ER-A19F	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.0556
p.R318L	DO37679	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.0556
p.R318L	DO47578	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.0556
p.D302N	TCGA-DU-6407	LGG	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.3056
p.D302N	DO22295	LGG	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.3056
p.P299S	TCGA-EB-A41A	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.3333
p.P299S	TCGA-EE-A2MM	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.3333
p.P299S	DO222678	MELA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.3333
p.P299S	DO229453	SKCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.3333
p.P299S	DO37770	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.3333
p.P299S	DO37429	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.3333
p.D296Y	TCGA-EO-A22R	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.25
p.D296Y	DO42713	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.25
p.D296H	TCGA-ZF-AA4V	BLCA	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.25
p.D296H	DO219087	BLCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.25
p.E311G	DO223046	ESCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.25
p.E311K	DO220880	MELA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.25
p.E311K	SIDM00861	Ovarian Carcinoma	GDSC	FIPYRD	LIG_APCC_ABBA_1	0.25
p.E311K	ES-2	ovary	COSMIC	FIPYRD	LIG_APCC_ABBA_1	0.25
p.R310Q	SIDM00933	Breast Carcinoma	GDSC	FIPYRD	LIG_APCC_ABBA_1	0.2778
p.R310Q	CAL-51	breast	COSMIC	FIPYRD	LIG_APCC_ABBA_1	0.2778
p.L313F	SIDM01519	Head and Neck Carcinoma	GDSC	FIPYRD	LIG_APCC_ABBA_1	0.1944
p.R316Q	ACH-000856	Breast Cancer	CCLE	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.R316Q	CAL-51	breast	COSMIC	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.E317K	ACH-000906	Ovarian Cancer	CCLE	FIPYRD	LIG_APCC_ABBA_1	0.0833
p.E317K	ES-2	ovary	COSMIC	FIPYRD	LIG_APCC_ABBA_1	0.0833
p.K297N	ACH-000986	Colon/Colorectal Cancer	CCLE	FIPYRD	LIG_APCC_ABBA_1	0.2778
p.K297N	HT-115	large_intestine	COSMIC	FIPYRD	LIG_APCC_ABBA_1	0.2778
p.S295I	SNU-1040	large_intestine	COSMIC	FIPYRD	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FIPYRD

Degron related mutations and impact score

Drug responses associated with KIF1B mutations

All proteins holding degron of FIPYRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	LIG_APCC_ABBA_1	303:308	FIPYRD	APC,CDC20,FZR1	0.979	More...
Q12756	Kinesin-like protein KIF1A	LIG_APCC_ABBA_1	303:308	FIPYRD	APC,CDC20,FZR1	0.5088	More...