DegronMD

Uniprot ID: Q12756

Source protein: Kinesin-like protein KIF1A

Source gene: KIF1A

Class: LIG_APCC_ABBA_1

Location: 303:308

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5088

ASA_SCORE: 64.5667

COIL: 0.678

CONS_SCORE: 0.7444

DSS_SCORE: 0.2304

HELIX: 0.245

FCONS_SCORE: 1.2854

RIG_SCORE: 0.8601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K296M	TCGA-60-2726	LUSC	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.25
p.K296M	DO27484	LUSC	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.25
p.R307Q	TCGA-A5-A0G1	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.6218
p.R307Q	DO42472	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.6218
p.R316L	TCGA-CV-7102	HNSC	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.R316L	TCGA-G2-A2EO	BLCA	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.R316L	TCGA-HE-7128	KIRP	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.R316L	DO456	BLCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.R316L	DO14194	HNSC	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.R316L	DO20796	KIRP	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.P305L	TCGA-DA-A1HY	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.6471
p.P305L	DO37409	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.6471
p.F303L	TCGA-DI-A1BU	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.587
p.F303L	DO42023	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.587
p.R316Q	TCGA-GV-A3QF	BLCA	TCGA	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.R316Q	DO471	BLCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.1111
p.T301K	DO228948	LICA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.7222
p.N293K	DO228971	LICA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.0556
p.P305T	DO229031	LICA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.7031
p.T301R	DO46483	OV	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.7222
p.E317K	DO218892	SKCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons