DegronMD - Q12756(KIF1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1505T	TCGA-2W-A8YY	CESC	TCGA	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation altering degron motif	0.7139
p.K296M	TCGA-60-2726	LUSC	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.25
p.K296M	DO27484	LUSC	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation substituting flanking lysine	0.25
p.R307Q	TCGA-A5-A0G1	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.6218
p.R307Q	DO42472	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.6218
p.H1494Q	TCGA-BG-A0MQ	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.1111
p.R316L	TCGA-CV-7102	HNSC	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R316L	TCGA-G2-A2EO	BLCA	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R316L	TCGA-HE-7128	KIRP	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R316L	DO456	BLCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R316L	DO14194	HNSC	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R316L	DO20796	KIRP	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.P305L	TCGA-DA-A1HY	SKCM	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.6471
p.P305L	DO37409	SKCM	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.6471
p.F303L	TCGA-DI-A1BU	UCEC	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.587
p.F303L	DO42023	UCEC	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.587
p.T1492I	TCGA-EO-A22U	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.0556
p.R316Q	TCGA-GV-A3QF	BLCA	TCGA	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R316Q	DO471	BLCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.1111
p.R1515W	DO9594	COAD	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.1111
p.R1515W	DO49466	PACA	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.1111
p.R1515W	DO41319	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.1111
p.T301K	DO228948	LICA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation blocking phosphorylation signal	0.7222
p.N293K	DO228971	LICA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0556
p.P1509T	DO228971	LICA	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.2778
p.P305T	DO229031	LICA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation altering degron motif	0.7031
p.T301R	DO46483	OV	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation blocking phosphorylation signal	0.7222
p.G1517S	DO37251	READ	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.0556
p.E317K	DO218892	SKCA	ICGC	FIPYRD	LIG_APCC_ABBA_1	303:308	Mutation rewiring degron network	0.0833
p.S1510F	DO37515	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.25
p.S1495F	DO37515	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation blocking phosphorylation signal	0.5833
p.S1495Y	DO219452	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation blocking phosphorylation signal	0.5833
p.S1493L	DO41488	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.0833
p.G1498R	DO41361	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.2222
p.S1493T	ACH-002222	Leukemia	CCLE	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.0833
p.S1493T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LTPSST	DEG_SCF_FBW7_1	1502:1507	Mutation rewiring degron network	0.0833

Kaplan plot for KIF1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF1A

UniProt ID: Q12756

Entrez ID: 547

Protein name: Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF1A in